4376 papers
The study demonstrates that a newly synthesized quinazoline derivative, KDY23, exhibits potent and moderately selective antitumor activity against glioblastoma cells by inducing apoptosis and downregulating key genes in the EGFR/PI3K/AKT/mTOR signaling pathway.
This study develops and evaluates an explainable LightGBM machine learning model trained on US survey data to serve as a high-sensitivity baseline for the Wo'tosuga digital health platform, aiming to screen for diabetes risk in African populations while acknowledging the need for future retraining with local data to address current geographic limitations.
This ecological analysis of NFHS-6 (2023–24) data reveals that women's educational attainment is the dominant predictor of India's rising caesarean section rates, which have reached 27.2% nationally with a stark 3.2-fold disparity between private and public sectors, prompting calls for targeted clinical audits and pre-natal education to curb demand-side medicalisation.
This paper describes the co-design and development of a low-cost, scalable toolkit for community health workers and care teams, featuring training, reference guides, and action protocols, to better address patient employment needs and improve health outcomes.
This narrative review proposes a structured framework for using artificial intelligence to enable precision allocation of cardiometabolic therapies in diabetes and metabolic disease by integrating risk prediction, treatment prioritization, and causal effect estimation, while noting that current applications remain largely at the proof-of-concept stage and require rigorous validation before clinical deployment.
This phenomenological study of 17 older adults in Ghana's Ga West Municipality reveals that individuals living with stroke and hypertension actively engage in medical help-seeking and proactive recovery behaviors, underscoring the need for government investment in accessible, community-based multidisciplinary care centers to support their holistic rehabilitation.
This case report describes a 4-year-old boy with a rare congenital blind-ending dorsal prepubic sinus that, despite lacking a connection to the urinary tract, exhibited urethral-type histologic differentiation, supporting the theory that such anomalies may represent incomplete accessory urethral tracts treatable by complete surgical excision.
This longitudinal analysis of 5,875 children demonstrates that cast application, rather than the mere presence of a fracture, is the primary driver of radiographic surveillance burden in paediatric wrist injuries, supporting the implementation of tiered surveillance protocols to reduce unnecessary imaging.
This study suggests that robot-assisted adrenalectomy may mitigate the impact of the Mayo Adhesive Probability score on operative difficulty, making it a potentially advantageous surgical option for patients with high-risk perirenal anatomy compared to conventional laparoscopy.
This study demonstrates that serial myocardial enzyme levels, particularly LDH and α-HBDH, exhibit distinct "peak-at-day-3" trajectories in severe acute pancreatitis and that a derived Myocardial Injury Composite Index effectively predicts severe outcomes, especially in hypertriglyceridemic cases but not biliary ones.