14453 papers
This study demonstrates that Mechanical Digitorum Sensory Stimulation (MDSS) effectively improves upper-limb motor function and reduces spasticity in stroke patients by enhancing cortical excitability and functional connectivity, as evidenced by clinical assessments and fNIRS imaging.
This multistate Markov analysis of Chinese adults with cardiometabolic multimorbidity reveals that while loneliness primarily accelerates the onset of functional decline, the combination of loneliness and social isolation significantly impairs recovery from disability and increases post-disability mortality, resulting in a substantial reduction in expected years of independent living.
This study demonstrates that patient-derived organoid (PDO) drug sensitivity profiling effectively guides personalized treatment for tumors of uncertain differentiation, resulting in significantly improved progression-free survival and clinical outcomes compared to standard care.
This study demonstrates that modified coronectomy effectively prevents inferior alveolar nerve injury in high-risk mandibular third molar cases with minimal postoperative pain, despite requiring longer operative time, while revealing that residual root migration over 12 months is influenced by root length and morphology, with 5–10 mm roots showing the greatest stability.
This study demonstrates that while sperm telomere length shows no significant correlation with conventional semen parameters, chromatin protamination serves as the sole independent predictor of telomere length, revealing hidden molecular defects in normozoospermic men and highlighting its utility as a functional biomarker for paternal genomic integrity in fertility assessments.
This study reports a novel TPK1 tandem duplication identified via whole genome sequencing in a Chinese family with thiamine metabolism dysfunction syndrome 5, highlighting the diagnostic superiority of WGS for detecting copy number variants and emphasizing the critical need for high-dose, lifelong thiamine therapy to prevent neurological decline.
Analysis of 2024 BRFSS data reveals that both cost-related barriers and mental distress are independently associated with reduced cervical cancer screening adherence among U.S. women, suggesting that integrated financial and mental health interventions could improve screening uptake.
This study demonstrates that transcutaneous auricular vagus nerve stimulation effectively reduces the incidence of postoperative delirium in elderly colorectal cancer surgery patients, likely by inhibiting central nervous system injury markers and pro-inflammatory cytokines.
This 15-year longitudinal case report describes the first pediatric instance of abrupt-onset crescentic IgA nephropathy superimposed on glycogen storage disease type Ia, demonstrating that such atypical presentations require prompt renal biopsy and a dual-track therapeutic approach combining metabolic control with targeted immunosuppression to achieve durable clinical remission.
This single-center retrospective study of 25 patients demonstrates that higher preoperative endoscopic ultrasonography (EUS) wall-layer grades in rectosigmoid deep infiltrating endometriosis are significantly associated with more extensive bowel surgical management, suggesting EUS is a valuable tool for surgical planning and counseling despite not being a standalone indicator for segmental resection.