14453 papers
This retrospective landmark study demonstrates that a higher burden of deep sedation (RASS ≤ −3) within the first 72 hours of mechanical ventilation is significantly associated with increased in-hospital mortality in neurocritical patients, a finding that was directionally consistent across both MIMIC-IV and eICU cohorts.
This case report describes an extremely rare instance of cephalothoracoomphalopagus tetrabrachius tetrapus conjoined twins diagnosed via advanced ultrasound at 29 weeks, who were delivered at 33 weeks but died within an hour of birth, underscoring the critical importance of routine antenatal care for early diagnosis and informed family counseling.
This population-based cross-sectional study in Shaanxi Province, China, reveals a high prevalence (22.16%) of molar–incisor hypomineralization among 7- to 10-year-old children, with significant geographic variations and strong associations identified between the condition and specific early-life factors such as amoxicillin exposure and maternal diarrhea during the third trimester.
This retrospective cohort study of nonambulatory patients with Duchenne muscular dystrophy found that while posterior spinal fusion did not significantly alter early pulmonary function, forced vital capacity declined by two years post-surgery, with greater degrees of scoliosis correction paradoxically associated with larger reductions in pulmonary function, suggesting that the procedure's primary benefits lie in functional and quality-of-life improvements rather than pulmonary preservation.
This case report describes a rare instance of posterior reversible encephalopathy syndrome (PRES) triggered by enfortumab vedotin therapy in a patient with advanced urothelial carcinoma, highlighting the importance of early neuroimaging and prompt management to ensure rapid neurological and radiological recovery.
Using interpretable machine learning on 2022 Bangladesh Demographic and Health Survey data, this study demonstrates that XGBoost can accurately predict fertility-limiting preferences among married women, identifying age, number of living children, and contraceptive intention as key predictors while revealing that digital inclusion and mental health have minimal influence.
This paper reports two rare cases of spinal capillary hemangioma with combined intra- and extramedullary components presenting a "snowman-like" MRI appearance, highlighting the importance of including this benign tumor in the differential diagnosis for such imaging patterns despite its typical association with hemangioblastoma.
This case report describes a 34-year-old male with early-onset rectal adenocarcinoma and a strong family cancer history who was diagnosed with Li-Fraumeni Syndrome via the identification of a germline TP53 p.R337H variant, highlighting the critical need for genetic evaluation in young colorectal cancer patients.
This open-label, single-institution study from Eastern India demonstrates that a six-weekly low-dose regimen of nivolumab combined with oral metronomic triple chemotherapy (methotrexate, erlotinib, and celecoxib) achieves overall survival and progression-free survival comparable to standard immunotherapy schedules in advanced head and neck squamous cell carcinoma, while offering a more affordable, less disruptive, and well-tolerated treatment option with no immunologic adverse events or treatment-attributable deaths.
In a prospective randomized trial of men with large prostates (>60 g), bipolar and holmium laser enucleation demonstrated comparable erectile function recovery at six months, though bipolar enucleation was associated with superior ejaculatory outcomes.