📄 Category

medicine

4603 papers

📄 medicine

Knowledge, attitudes, and referral behavior of pediatric dentists regarding the early diagnosis of orthodontic anomalies: a cross-sectional survey

This cross-sectional survey of 120 pediatric dentists reveals that while practitioners hold strongly positive attitudes toward early orthodontic diagnosis and referral, they possess only moderate knowledge with specific gaps in treatment timing, highlighting a disconnect between their attitudes and preventive practices that underscores the need for enhanced education and inter-specialist collaboration.

Hande Özyürek, Zeynep Aybike Yelmer, Taha Özyürek2026-07-08
📄 medicine

Persistent Humoral Immunodeficiency with Rising Herpesvirus Loads Despite Successful IL-6 Blockade in a Patient with Idiopathic Multicentric Castleman Disease and IgM-λ Monoclonal Gammopathy

This case report describes a unique endotype of idiopathic multicentric Castleman disease with IgM-λ monoclonal gammopathy where successful IL-6 blockade resolved systemic inflammation and lymphadenopathy but failed to correct persistent humoral immunodeficiency or viral reactivation, highlighting that anti-inflammatory control does not guarantee immune reconstitution.

Jirong Cheng, Yi Yang2026-07-08
📄 medicine

From global targets to local inequalities: subnational projections of reproductive, maternal, newborn and child health coverage and mortality in Mozambique

This study reveals that while Mozambique has made progress in reproductive, maternal, newborn, and child health, national averages mask persistent geographic and socioeconomic inequalities that hinder 2030 targets, demonstrating that equitable subnational scale-up of interventions could avert significantly more deaths than uniform implementation.

Qin Li, Lu Ao, Kanduma Elsa, Shanquan Chen, Haijun Wang, Isaías Ramiro, Jay Pan2026-07-08
📄 medicine

Prolonged treatment-free remission after venetoclax in combination with a hypomethylating agent in acute myeloid leukemia with inv(16)

This paper reports the first case of sustained treatment-free remission in a patient with inv(16) acute myeloid leukemia treated with venetoclax and a hypomethylating agent, suggesting that carefully selected patients achieving rapid, deep molecular responses may successfully discontinue therapy despite the regimen's typical indefinite administration.

Morgan L. Shannon, Jared Wallace, Amy Kuo, Gabriel N. Mannis2026-07-08
📄 medicine

Improvements in Weight, Eating-Disorder Symptoms and Sleep Following Off-Label Leptin Treatment in an Adolescent with Chronic Anorexia Nervosa and Insomnia: A Case Report

This retrospective case report suggests that off-label metreleptin treatment in an adolescent with chronic anorexia nervosa and insomnia was associated with short-term improvements in weight, eating-disorder cognitions, and sleep architecture, followed by continued weight gain and subjective sleep improvement at a two-month follow-up, though these findings are limited by the inability to disentangle drug effects from concurrent weight gain and inpatient care.

Alexander Dück, Hang Zhu, Judith Melinat, Monika Kruzer, Christoph Berger, Michael Kölch, Martin Reinhardt, Hannes Brehm (…)2026-07-08
📄 medicine

Prevalence and Antibiotic Sensitivity Pattern of Uropathogens in Bangladesh: A Multi-Center Retrospective Study

This multi-center retrospective study in Bangladesh reveals that among 17.97% of growth-positive urine samples, *Escherichia coli* is the predominant uropathogen with high resistance to commonly prescribed antibiotics like ciprofloxacin and ceftriaxone, underscoring the urgent need for evidence-based, susceptibility-guided therapy and stricter antibiotic policies.

Md Al Hasan Mia, Tahmid Adeeb, Sayok Chakrabarty, Md Jannatul Islam Nabil, Kakali Halder, Sazzad Bin Shahid2026-07-08
📄 medicine

Systematic Review of Prognostic Factors in Elderly Patients Undergoing Primary Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction

This systematic review identifies key prognostic factors and validated risk scores, such as frailty and comorbidity burden, that guide decision-making for elderly STEMI patients undergoing primary PCI, confirming its superior long-term mortality benefits compared to non-invasive strategies.

Aaruni Saxena, Akhlaque Uddin, Shahnaz Jamil-copley, Nikola Sprigg2026-07-08
📄 medicine

Dynamics of PfHRP2 Antigen-Based Diagnostic Tool Efficiencies During High Seasonal Malaria Transmission

This study conducted in Southwest Nigeria during high malaria transmission season found that while the PfHRP2-based rapid diagnostic test demonstrated high sensitivity compared to PCR, its extremely low specificity and poor agreement with reference standards highlight significant limitations for routine clinical use.

Olugbenga Akinola, Omosalewa M. Adeniyi, Rasheedat Usman, Abiodun I Amusan, Grace O Gbotosho2026-07-08✓ Author reviewed ⓘ
📄 medicine

Micro-Environmental Variation in Exposure and Health Outcomes in Communities Surrounding the DeonarLandfill: A Zone-Based Assessment Integrating Microbial Load and Household-Level Data

This exploratory study of 100 households near Mumbai's Deonar landfill demonstrates that micro-environmental factors like drainage proximity and ventilation, rather than simple distance, create significant gradients in microbial exposure and respiratory health outcomes, supporting the need for zone-based assessment frameworks over conventional proximity models.

Mohammed Shadab Shah2026-07-08
📄 medicine

Diabetes Screening, Diagnosis, and Treatment Among Adults in Nigeria: A National Analysis of the 2023–2024 Nigerian Demographic and Health Survey (NDHS)

This national analysis of the 2023–2024 Nigerian Demographic and Health Survey reveals that while diabetes screening rates are modest, diagnosis and treatment uptake remain critically low with significant sociodemographic disparities, highlighting an urgent need to expand routine screening and strengthen primary care in Nigeria.

Henry Eziefule Nwankwo, Agozie Nworah, Florence Ubani, Chinedu Nwego, Micah Okwah, Ayodele Ayo-ige, Divine Emenuga, Onae (…)2026-07-08