📄 Category

medicine

4603 papers

📄 medicine

Oncological outcomes and recurrence patterns of obstructive colon cancer managed with self-expandable metallic stent as a bridge to surgery: A retrospective cohort study

This retrospective cohort study of 382 patients with obstructive colon cancer found that while using self-expandable metallic stents as a bridge to surgery resulted in comparable overall survival, it was associated with significantly worse recurrence-free survival and a higher rate of liver-specific recurrence compared to non-stent management.

Makoto Hasegawa, Tomoyuki Momma, Jun Tsukioka, Takahiro Kawamata, Chiaki Takiguchi, Satoshi Fukai, Takahiro Sato, Misato (…)2026-07-08
📄 medicine

Evaluation of the ‘Shared Community Follow-up’ after a germ cell tumour (II): Patient and healthcare professional experiences of remote follow-up using PROMs

This mixed-methods study evaluates the Shared Community Follow-up model for germ cell tumours, finding that while integrating remote patient-reported outcomes with community-based care is feasible, safe, and valued by stakeholders, its successful scalability requires addressing challenges related to workforce capacity, technological infrastructure, and inter-centre communication.

Oana C. Lindner, Gwendolyn Saalmink, Elaine Dunwoodie, Dan P. Stark2026-07-08
📄 medicine

Induced alanine auxotrophy as a therapeutic strategy against Mycobacterium tuberculosis

This study identifies and optimizes hydroxamic acid compounds, particularly TI-801, as potent inhibitors of the essential *Mycobacterium tuberculosis* enzyme AlaA, demonstrating that inducing alanine auxotrophy via this target effectively kills the bacteria both intracellularly and in a murine infection model.

Menna-Allah W. Shalaby, Nagabhushana C. Beeralingappa, Annadka Shrinidhi, Gaelle G. Makafe, Evan Nece, Aditya Patwardhan (…)2026-07-08
📄 medicine

Exploring the views of Swedish Medical Students on Physician- Assisted Dying: A Quantitative and Qualitative Analysis

This 2024–2025 mixed-methods study of 2,107 Swedish medical students reveals that a majority support the legalization of physician-assisted dying, a stance strongly influenced by ethical frameworks prioritizing autonomy and religious beliefs rather than by the specific terminology used, while highlighting significant polarization and concerns regarding mandatory participation.

August Näsström, Sam Polesie, Jenny Lindberg2026-07-08
📄 medicine

Intraoperative Submucosal Injection of Triamcinolone Acetonide Combined with Oral Prednisone for Prevention of Esophageal Stricture after ESD for Circumferential Superficial Tumors: A Retrospective Pilot Study

This retrospective pilot study demonstrates that combining intraoperative submucosal triamcinolone acetonide injection with a short course of oral prednisone is a safe and effective strategy for significantly reducing the incidence of esophageal stricture following endoscopic submucosal dissection for circumferential superficial tumors.

Xiufan Ni, Zhen Zhu, Xijing Shi, Jian Yin, Li Zhang, Sujun Gao, Lei Chen2026-07-08
📄 medicine

The role of Artificial Intelligence in interventions to reduce physical inactivity: A systematic review

This systematic review of 17 randomized controlled trials found no strong evidence that artificial intelligence-assisted interventions significantly reduce physical inactivity in high-income countries, though they may modestly increase step counts, while highlighting the need for future research to address methodological limitations and equity concerns.

Sean Harrison, Joelle Kirby, Jessica M Armitage, Rhiannon Evans, Siang Ing Lee, James Lewis, Clarie Tatton, Sophie Robin (…)2026-07-08
📄 medicine

Investigating the Correlation Between Neutrophil-to-Lymphocyte Ratio and Blood-Based Pathological Markers of Alzheimer's Disease and Cognitive Impairment

This study demonstrates that an elevated neutrophil-to-lymphocyte ratio (NLR) is independently associated with poorer cognitive function and higher plasma levels of Alzheimer's disease-related biomarkers (GFAP, NfL, and p-tau181), suggesting NLR serves as a cost-effective peripheral indicator of neuroinflammation and cognitive decline in AD.

Chunhua Liang, Xueqin Yan, Guo Hong, Yanxing Zhou, Chengjie Li, Jing Tian, Cuimei Wei, Jingyun Ding, Guojun Yao, Chen Li (…)2026-07-08
📄 medicine

Familial Case Series of Neurodegenerative Disorders With Hematobiochemical Correlates: Insights From Four Related Patients

This case series of four related patients with a confirmed *ATXN3* mutation illustrates the variable expressivity of familial neurodegenerative disorders, where divergent phenotypes ranging from Spinocerebellar Ataxia Type 3 to hereditary spastic paraplegia and neuropathy are accompanied by shared systemic manifestations including hematological anomalies and autonomic dysfunction.

Neha Poloju, Venkataramana Kandi2026-07-08