📄 medicine

Evaluation of Anti-diarrheal Activity of 80 % Methanol Crude Root Extract and Solvent Fractions of Ficus Thonningii B.( Moraceae) in Swiss Albino Mice

This study validates the ethnomedicinal use of *Ficus thonningii* roots for treating diarrhea by demonstrating that its 80% methanol crude extract and solvent fractions, particularly the aqueous fraction, significantly inhibit castor oil-induced diarrhea, enteropooling, and intestinal motility in Swiss albino mice in a dose-dependent manner.

Sisay Tarekegn, Muluken Adela, Mestayet Geta, Assefa Belay2026-07-08
📄 medicine

Advancing the Hong Kong Centre for Medical Products Regulation: A Mixed-Methods Assessment and Strategic Blueprint

This mixed-methods study evaluates the pre-launch maturity of the upcoming Hong Kong Centre for Medical Products Regulation (CMPR), identifying current gaps in primary review and real-world evidence integration while proposing a ten-year strategic blueprint to advance its transition to an independent primary authority through workforce development, regulatory innovation, and Greater Bay Area harmonization.

Donglei Mao, Yuk-Lin Lo, Man-Cheong Fung, Sunny Tam, Karl Tsim2026-07-08
📄 medicine

Motor and Cognitive Improvements Following Non-Invasive Brain Stimulation with kTMP: A Case Study of Cerebellar Stroke

This case study demonstrates that amplitude-modulated kilohertz transcranial magnetic perturbation (AM-kTMP) is a safe and promising non-invasive intervention that improved motor and cognitive function in a 78-year-old patient with cerebellar ataxia following a hemorrhagic stroke.

Amanda Chirino-Pérez, Christina Merrick, Fredy Miranda-Casasola, Ludovica Labruna, Richard B. Ivry2026-07-08
📄 medicine

AI-Driven Paraphrasing and Evidence Recycling in Global Health Meta-Analyses: Introducing the EVIDENCE Framework for Detection and Prevention

This paper introduces the EVIDENCE Framework, a practical methodology designed to detect and prevent "evidence recycling"—the AI-driven paraphrasing of existing research that creates an illusion of novelty—by utilizing a dependency matrix to ensure source traceability in global health meta-analyses.

Ally Mwambela, Godfrey Katusi, Hawa Ngasongwa, Azizatul Hamidiyah2026-07-08
📄 medicine

Bond Strength of Three Ion-Releasing Restorative Materials to Primary Dentin Following Silver Fluoride Pretreatment: An In Vitro Study

This in vitro study found that while the alkasite material Cention Forte generally exhibited superior shear bond strength to primary dentin compared to glass ionomer cements, silver fluoride pretreatment equalized the performance of all three materials and slightly reduced Cention Forte's bond strength, with aging having a minimal overall effect.

Zeynep Keleş Tepeli, Zülfikar Zahit Çiftçi, Nurgül Çetin Tuncer2026-07-08
📄 medicine

Risk of Diabetic Ketoacidosis with Glucagon-Like Peptide-1 Receptor Agonists: A Systematic Review and Meta-analysis

This systematic review and meta-analysis of 32 studies involving over 327,000 users indicates that while diabetic ketoacidosis is an uncommon complication of Glucagon-Like Peptide-1 Receptor Agonists overall (0.7%), the risk is significantly higher in patients with type 1 diabetes (2.0%) compared to those with type 2 diabetes (0.3%).

Nasser Alkhushaym, Wadha Almutairi, Shahad Alanazi, Reem Balharith, Abdullah Alhifany, Imad R Musaa2026-07-08
📄 medicine

Hypertension Screening, Diagnosis, and Treatment Gaps in Nigeria: A National Analysis of the 2023-2024 Nigeria Demographic and Health Survey

A secondary analysis of the 2023–2024 Nigeria Demographic and Health Survey reveals that while substantial sex disparities exist in hypertension screening and diagnosis, with men significantly less likely to be detected than women, the subsequent treatment cascade shows no gender differences, indicating that Nigeria's primary challenge in hypertension management is detection rather than treatment access.

Henry Eziefule Nwankwo, Osarenoma Mathilda Omonfuegbe, Okolo Emeka Herbert, Izuchukwu Anaesiuba, Chijioke Chizoba Egwu (…)2026-07-08
📄 medicine

Risk of adverse pregnancy outcomes after Chlamydia trachomatis infection or pelvic inflammatory disease: a long-term cohort study

This long-term cohort study of over 5,700 individuals found that while a history of pelvic inflammatory disease significantly increases the risk of miscarriage, past Chlamydia trachomatis infection alone was not significantly associated with miscarriage, recurrent miscarriage, or preterm birth.

Zoïe W. Alexiou, Eline Op de Coul, Christian J.P.A. Hoebe, Henry J.C. de Vries, Servaas A. Morré, Nicole H.T.M. Dukers-M (…)2026-07-08