4603 papers
This systematic review evaluates exosome–liposome hybrid nanovesicles as a promising theranostic platform for breast cancer that enhances drug delivery and efficacy while identifying critical standardization and manufacturing challenges that must be addressed to enable clinical translation.
Based on a weighted analysis of the 2021 Youth Risk Behavior Survey, this study reveals that bisexual adolescents in the U.S. face a significantly higher risk of binge drinking compared to their heterosexual peers, highlighting a critical need for targeted public health interventions.
This paper assesses the readiness of the Philippines, Thailand, and Malaysia to implement pathogen genomics for antimicrobial resistance control, identifying strong foundational capabilities alongside critical gaps in data integration and governance that must be addressed to enable coordinated, high-impact surveillance and response across the ASEAN region.
This study demonstrates that novel PARG inhibitors selectively eliminate cancer cells, including non-proliferating and base excision repair-deficient populations, by inducing toxic PAR accumulation that triggers parthanatos and apoptosis independently of NAD⁺ depletion or DNA replication.
This study reveals that in Nigeria, commercial fat spreads marketed as "low-fat" paradoxically contain significantly higher sodium levels than their medium-fat counterparts, potentially undermining cardiovascular health goals by shifting consumers from fat reduction to excessive salt intake.
This community survey study reveals that financial constraints, fear of surgery, and geographical limitations are the primary barriers preventing timely eye care access, resulting in a critically low utilization rate where 68.1% of participants have never visited an eye care facility.
This retrospective study demonstrates that indocyanine green (ICG)-assisted microscopic varicocele ligation is a safe and effective short-term treatment that significantly reduces operation time and improves the precision of vascular identification compared to conventional microscopy.
The study demonstrates that a newly synthesized quinazoline derivative, KDY23, exhibits potent and moderately selective antitumor activity against glioblastoma cells by inducing apoptosis and downregulating key genes in the EGFR/PI3K/AKT/mTOR signaling pathway.
This study develops and evaluates an explainable LightGBM machine learning model trained on US survey data to serve as a high-sensitivity baseline for the Wo'tosuga digital health platform, aiming to screen for diabetes risk in African populations while acknowledging the need for future retraining with local data to address current geographic limitations.
This ecological analysis of NFHS-6 (2023–24) data reveals that women's educational attainment is the dominant predictor of India's rising caesarean section rates, which have reached 27.2% nationally with a stark 3.2-fold disparity between private and public sectors, prompting calls for targeted clinical audits and pre-natal education to curb demand-side medicalisation.