📄 medicine
A stochastic, physiology-based digital twin model of hemostasis and oxygenation in trauma resuscitation
This paper presents a stochastic, physiology-based digital twin model of hemostasis and oxygenation that simulates trauma resuscitation to demonstrate the superior efficacy of cold-stored low titer group O whole blood (LTOWB) over conventional component therapy in reducing critical hemostatic deficits and improving survival for severe hemorrhagic shock, while also offering a platform for precision transfusion strategies and blood bank demand forecasting.
Casey Vieni, Anika Iftekharuddin, Kevin Ward, Roland Pittman, Andrew Norgan, Matthew Neal, Darrell Triulzi, Phillip Spin (…)2026-07-08