14817 papers
This retrospective study of 638 patients identifies male sex, higher body mass index, neoadjuvant chemoradiotherapy, and mid-rectal tumor location as independent predictors of increased surgical difficulty in robotic-assisted rectal cancer surgery, providing a basis for improved preoperative risk stratification.
This study demonstrates that closed-loop neuromodulation provides safe, cumulative, and patient-specific seizure control for drug-resistant epilepsy through the plastic reorganization of local inhibitory microcircuits and suppression of long-range epileptic propagation, as evidenced by distinct intracranial gamma-band enhancements and scalp slow-wave changes.
This longitudinal study of older adults with hypertension and/or diabetes reveals that greater diversity in social participation, particularly engaging in three to four different activity types, is significantly associated with better long-term cognitive trajectories, whereas vigorous physical activity showed no significant link to cognitive function.
This retrospective study utilizing targeted next-generation sequencing identifies advanced age, elevated BMI, specific respiratory symptoms, and a distinct shift toward fungal and viral co-infections as key risk factors and pathogen profiles distinguishing severe from mild Influenza A(H1N1)pdm09 pneumonia.
This cross-sectional latent class analysis of over 189,000 U.S. adults aged 60 and older reveals that fall burden varies significantly across six distinct multidimensional profiles, demonstrating that functional, cognitive, mobility, and social characteristics are more predictive of fall risk than morbidity or cardiometabolic treatment status alone.
This study develops a data-driven, risk-stratified public health framework for full-cycle skin health management in people living with HIV by integrating national survey data and machine learning to create a closed-loop care pathway that improves early detection, treatment adherence, and quality of life.
This quasi-experimental study involving 136 second-year medical students found that while both facilitator-led and AI-mediated problem-based learning (PBL) significantly improved pharmacology knowledge, facilitator-led PBL resulted in superior critical thinking and group dynamics, whereas AI-mediated PBL offered better access to resources and discussion, suggesting a hybrid model combining both approaches may be most effective for medical education.
This study demonstrates that all-trans retinoic acid (ATRA) protects against doxorubicin-induced cardiomyocyte ferroptosis by disrupting the KEAP1-NRF2 interaction to stabilize NRF2 and activate the NRF2-SLC7A11 antioxidant pathway.
The BARISTA trial is a prospective, single-arm, multicenter study enrolling 200 patients across 14 Belgian centers to evaluate the two-year safety and efficacy of the Restorer iliac stent system for treating symptomatic aorto-iliac lesions, with the goal of providing comparative evidence to guide stent selection in complex disease.
In a retrospective study of 236 neonates at an Egyptian tertiary NICU, hepatobiliary dysfunction affected 27.1% of admissions, was independently predicted by total parenteral nutrition exposure and multi-organ failure, and served as a marker of severe systemic illness associated with higher mortality without independently driving overall death rates.