📄 medicine

Predictors of Sleep Quality in Patients Undergoing Open-Heart Surgery: A Hierarchical Regression Analysis A Short Running Title: Predictors of sleep after open-heart surgery

This study of 157 open-heart surgery patients in a cardiovascular ICU found that sleep quality is primarily predicted by symptom burden (pain and fatigue) and environmental stressors rather than demographic or clinical characteristics, explaining 35.1% of the variance in sleep outcomes.

Ezgi ARSLAN, Zehra BALCIK2026-10-12
📄 medicine

Effectiveness of Nursing Interventional Package on Vascular Symptoms, Quality Of Life and Perinatal Outcome among Pregnant Women with Pregnancy Induced Hypertension: A Pilot Interventional Study

This pilot quasi-experimental study demonstrates that a structured nursing interventional package significantly reduces vascular symptoms and improves quality of life among pregnant women with pregnancy-induced hypertension, although its impact on perinatal outcomes requires further investigation with larger sample sizes.

Nithya Natarajan, Selvanayaki Venkatesan, Judie Arulappan2026-10-12
📄 medicine

Everolimus therapy in a patient with tuberous sclerosis and a mutation in the LRP5 gene

This case report describes a patient with tuberous sclerosis complex and a heterozygous LRP5 variant who experienced progressive renal enlargement and cystic disease despite everolimus therapy, representing the first documented instance of this specific genetic association.

Vesna Stojanovic, Milica Kovacevic, Nina Brkic, Dragana Simic, Marijana Savin, Maja Samardzic Lukic, Natasa Kovac, Aleks (…)2026-10-12
📄 medicine

Exploring protective and resilience-promoting factors for maternal mental health in low- and middle-income countries (LMICs): A qualitative thematic analysis of patient advocacy content

This qualitative thematic analysis of patient advocacy content from Action on Preeclampsia Ghana identifies key protective and resilience-promoting factors for maternal mental health in low- and middle-income countries, highlighting the critical roles of institutional support, healthcare system effectiveness, family networks, psychological counseling, and community education in mitigating the mental health challenges associated with preeclampsia.

Mohammed Salim Sulley Wangabi, Amelie E Nithammer, Kitty.W.M Bloemenkamp, Hannah B Amoakoh, Koiwah Koi-Larbi, Diederick (…)2026-10-12
📄 medicine

Strategies to improve HIV prevention service uptake among young women who sell sex in sub-Saharan Africa: A scoping review

This scoping review synthesizes evidence from 30 studies in sub-Saharan Africa to identify that comprehensive, community-driven strategies—particularly peer-led outreach, mobile health initiatives, and integrated youth-friendly services—are essential for improving HIV prevention service uptake among young women who sell sex, while highlighting a critical need for further interventional research in Central and West Africa.

Prudence Tatiana Nti Mvilongo, Christiana Noestlinger, Jef Vanhamel, Kristien Michielsen, Patrick Achiangia Njukeng, Ber (…)2026-10-12
📄 medicine

Sleep Quality Among Women with Endometriosis in Bangladesh: A Hospital- Based Cross-Sectional Study

This hospital-based cross-sectional study conducted in Bangladesh reveals that poor sleep quality is highly prevalent among women with endometriosis and is significantly associated with pain-related symptoms such as dyspareunia, dysmenorrhea, and pelvic pain, highlighting the need for routine sleep assessments in clinical management.

Muhammad Muztoba, Afsana Afrose, Mubashira Marzan, Munima Haque2026-10-12
📄 medicine

Ultrasound-Activated Piezocatalytic Microneedles Rescue Calcitonin Gene-Related Peptide- Dependent Neuroimmune Homeostasis to Promote Regeneration of Infected Diabetic Wounds

This study presents a synergistic strategy using ultrasound-activated, protease-responsive microneedles loaded with piezocatalytic nanorods and CGRP to simultaneously eradicate bacterial biofilms, modulate the wound microenvironment, and restore neuroimmune signaling, thereby accelerating the regeneration of infected diabetic wounds.

Zhangqi Lai, Guo Zhang, Yan Zhang, Haijuan Teng, Miaochen Wang, Jialong Chen, Bangguo Zhou2026-10-12
📄 medicine

Sublingual vaccination by chitosan-based patch protected aged mice from influenza virus infection

This study demonstrates that a chitosan-based sublingual patch delivering a subunit influenza vaccine provides superior protection against infection in aged mice compared to traditional injections, likely by leveraging age-specific immune mechanisms involving enhanced B cell activation and neutrophil recruitment despite lower antibody levels.

ROVERA Renaud, COIFFIER Céline, GARAPON Cynthia, FERRARO Sandra, COLOMB Evelyne, Sophia DJEBALI, Claire MONGE2026-10-12