4603 papers
This study reveals a spatial dissociation in Parkinson's disease where subcortical microstructural alterations are strongly linked to presynaptic dopaminergic terminal loss, while cortical changes exhibit consistent, neuroinflammation-related associations with dopaminergic markers.
The orally active apelin receptor agonist CMF-019 crosses the blood-brain barrier to restore microglial metabolism, enhance amyloid-β clearance, and improve cognitive functions in Alzheimer's disease mouse models.
This study validates the Brazilian Portuguese version of the SOS-scale as a reliable and highly accurate tool for detecting iatrogenic withdrawal syndrome in critically ill children, demonstrating strong correlation with the WAT-1 and establishing an optimal diagnostic cut-off score of ≥ 4.
In a retrospective multicenter study of anticoagulated patients hospitalized with upper gastrointestinal bleeding, the specific class of anticoagulant did not predict in-hospital mortality or other clinical outcomes, whereas admission serum creatinine was identified as an independent predictor of death.
This case report details the successful total resection of an extremely rare craniovertebral junction chondromyxoid fibroma with myogenic differentiation and mutant-pattern P53 expression using a precision multimodal surgical approach, highlighting the tumor's potential for malignant transformation and the critical need for rigorous surveillance and targeted therapeutic strategies.
This retrospective cohort study of 265 patients undergoing one-hole split endoscopy for lumbar disc herniation demonstrates that preoperative sarcopenia and fatty infiltration in paraspinal and gluteal muscles are independent predictors of chronic postoperative low back pain and inferior long-term functional outcomes, suggesting that muscle-sparing surgical techniques alone cannot fully compensate for pre-existing biomechanical impairments.
This study of over 111,000 participants across Chinese, English, and European cohorts found that a higher metabolic-vascular burden is modestly associated with an increased risk of subsequent Parkinson's disease, though the strength of this association varies significantly by population context.
This large retrospective cohort study of over 384,000 pregnancies found that several pre-pregnancy chronic health conditions are significantly associated with an increased risk of spontaneous abortion, leading to the development of an exploratory risk score that showed moderate discrimination but requires further validation before clinical application.
This study demonstrates that two-week postoperative T10 tilt is an independent prognostic marker for proximal junctional kyphosis and failure in adult spinal deformity patients with an upper instrumented vertebra at T9 or T10, offering modest predictive value comparable to or slightly better than L1 pelvic angle for early risk assessment.
This study utilizes single-cell and spatial profiling to map the heterogeneous distribution and activity of cysteine cathepsins across breast cancer ecosystems, revealing that integrating protease abundance and activity with target antigen expression is crucial for optimizing the design and patient stratification of protease-cleavable antibody-drug conjugates.