📄 medicine

Genomic Copy Number Variation Profiling of Pleural Effusion cfDNA via LP-WGS for Precision Diagnosis and Prognostic Stratification in Lung Adenocarcinoma-associated Malignant Pleural Effusion running title: cfDNA CNV for LUAD-MPE Diagnosis and Prognosis

This study demonstrates that low-pass whole-genome sequencing-based copy number variation profiling of pleural effusion cfDNA is a highly sensitive, noninvasive, and cost-effective tool for accurately diagnosing lung adenocarcinoma-associated malignant pleural effusion and stratifying patient prognosis, outperforming traditional cytology and CEA testing.

Yujia Liu, Chao Shi, Haosong Zhou, Fangping Wang, Yupeng Liang, Xin Gan, Longhua Sun, Quqin Lu, Shiwen Luo2026-07-07
📄 medicine

Prophylactic PEG-rhG-CSF Is Associated With Fewer Severe Neutropenic Events and Preserved Chemotherapy Delivery During Platinum-Taxane-Based Concurrent Chemoradiotherapy for Locally Advanced Cervical Cancer: A Real-World Study Using Inverse Probability of Treatment Weighting

In a real-world study of locally advanced cervical cancer patients undergoing platinum-taxane-based concurrent chemoradiotherapy, prophylactic PEG-rhG-CSF significantly reduced severe neutropenic events and improved chemotherapy delivery compared to reactive short-acting support.

Shuishui Yin, Liu He, Xingzhou Tang, Bolv Zhu, Yuanli Zhou2026-07-07
📄 medicine

Machine Learning to Optimize Busulfan Exposure and Predict Survival in HSCT: Toward Personalized Dosing Strategies

This study demonstrates that machine learning models integrating clinical and pharmacokinetic variables outperform traditional methods in predicting busulfan exposure and survival, thereby enabling more precise, personalized dosing strategies for patients undergoing hematopoietic stem cell transplantation.

Dorian Protzenko, Laurent Bourguignon, Clara Boérie, Benjamin Bouchacourt, Raynier Devillier, Joseph Ciccolini2026-07-07
📄 medicine

High-Intensity Theatre Lists for Robot-Assisted Thoracic Resection: a proof-of-concept series

This proof-of-concept study demonstrates that a high-intensity theatre model utilizing parallel anaesthetic preparation enables the safe and efficient completion of fifteen major robot-assisted thoracic resections with 100% list completion and zero mortality, significantly increasing surgical throughput without additional resources.

Nabih Berjaoui, micayla pather, Fuhazia Arif, Craig Johnstone, George Christodoulides, Hani Abdalla, Imran Ahmed, Abulla (…)2026-07-07
📄 medicine

Multimodal deep learning enables precise early-versus-late ARCO stratification at the critical threshold for hip preservation in osteonecrosis of the femoral head

This study developed and validated an interpretable multimodal deep learning framework that integrates biparametric MRI sequences with clinical parameters to achieve highly accurate, objective stratification of early- versus late-stage osteonecrosis of the femoral head, thereby aiding critical decision-making for hip preservation.

Siyuan Li, Huimin Huang, Yetong He, Xiaowan Zhang, Xiaoxia Li, Lin Wang, Wei He, Xiaorui Han, Xudong Huang, Gengxin Chen2026-07-07
📄 medicine

Transsectoral optimization of sepsis care processes based on interoperable routine data (optiSEP): Results of a monocentric pilot study

This monocentric pilot study demonstrates that merging routine data across emergency, inpatient, and intensive care sectors is feasible and effectively reveals heterogeneities in sepsis care processes, thereby identifying critical areas for optimization to improve patient outcomes.

Angela Daniela Fuchs, Alexandra Ramshorn-Zimmer, Leonard Martin Weber, Manuel Feisst, Marieke Witt, Fabian Kueck, Rainer (…)2026-07-07
📄 medicine

Global Research Landscape of Natural Medicines for Lower Urinary Tract Symptoms: Bibliometric and Clinical Trial Analysis

This study utilizes bibliometric analysis of 497 publications and clinical trial data to map the global research landscape of natural medicines for lower urinary tract symptoms, highlighting China's leading publication output, the United States' historical influence and clinical trial contributions, and the field's evolution toward elucidating pathological mechanisms for effective clinical implementation.

Qi Xiong, Lin Chen, Jin Yang, Yafei Yang, Qiuxia Ding2026-07-07
📄 medicine

Comfort and Preference during Prone Upper Thoracic Spinal Manipulation in Various Head Positions

This study demonstrates that head rotation position significantly influences patient preference and comfort during prone upper thoracic spinal manipulation, with full rotation (100% of maximal range of motion) being rated as less preferred, less comfortable, and receiving lower overall ratings compared to neutral and moderate rotation positions.

Simon Wang, Marissa Lee, Brooke Hildenbrand, Malak Eid, Steve Tran, Nicole Smith, David Starmer, Martha Funabashi2026-07-07
📄 medicine

Transurethral Robotic Waterjet Ablation vs Single-Port Robotic Transvesical Simple Prostatectomy for Large Prostates Over 100 cc: a Comparative Analysis of Short-Term Operative Outcomes

This comparative analysis demonstrates that single-port robotic transvesical simple prostatectomy and transurethral robotic waterjet ablation offer similar short-term safety and efficacy for prostates exceeding 100 cc, despite the latter's advantages in operative time and reduced blood loss being offset by a higher need for continuous bladder irrigation.

Jacob O’Hara, Abinav Udaiyar, Mutahar Ahmed, Alina Chiccarine, Ji Whae Choi, Katherine Kim, Milan Patel, Pranesh Rajendr (…)2026-07-07