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Efficacy and Safety of High-Dose versus Low-dose methylprednisolone pulse therapy for IgA vasculitis Nephritis: a retrospective observational study

This retrospective observational study of 122 pediatric patients with IgA vasculitis nephritis and limited crescent formation found that while high-dose methylprednisolone pulse therapy achieved faster clinical remission and higher response rates at 1 and 3 months compared to low-dose therapy, both regimens demonstrated comparable long-term efficacy at 6 and 12 months, with the high-dose approach carrying a significantly higher risk of adverse reactions.

Lan Huang, Yang Yue, Yuanhui Zhu, Houhua Hao, Fengjun Guan2026-10-13

📄 medicine

“Proactive Path to Relief”: A Qualitative Exploration of Women’s Decision-Making Processes in Managing Menopausal Symptoms

This qualitative study conducted in Iran reveals that women navigate the menopausal transition through a dynamic, individualized "Proactive Path to Relief" shaped by personal, social, and cultural factors, ultimately calling for patient-centered care and shared decision-making to support symptom management.

Narjes Bahri, Robab Latifnejad Roudsari2026-10-13

📄 medicine

What are the key risk factors for drug-related problems in Emergency Departments? A multinational modified Delphi study

This multinational modified Delphi study engaged 40 healthcare professionals to reach consensus on key risk factors for drug-related problems in Emergency Departments, identifying high-risk prehospital drug administration, pharmacist intervention requests, and chronic drug use as the most relevant factors while highlighting the need for prospective validation of these findings.

Javier Ramos-Rodríguez, Jesús Ruíz-Ramos, Susana Redondo-Capafons, Gema Muñoz-Gamito, Caridad Pontes-García, José Manuel (…)2026-10-13

📄 medicine

Migration push and pull factors of Namibian diagnostic radiographers in the diaspora

This qualitative study reveals that Namibian diagnostic radiographers migrate abroad primarily due to domestic push factors such as limited career advancement, low pay, and poor working conditions, which are contrasted by pull factors from destination countries offering structured career progression, higher salaries, and well-equipped facilities.

Leena Uunona, Mondjila Amkongo, Festus Shidolo, Luzanne Kalondo2026-10-13

📄 medicine

Chitinase-1 inhibition attenuates airway hyperresponsiveness and type 2 airway inflammation in allergen-driven and TGF-β-driven murine models of airway remodeling

This study demonstrates that inhibiting Chitinase-1 with kasugamycin reduces airway hyperresponsiveness and type 2 inflammation in multiple murine models of airway remodeling, identifying CHIT1 as a promising therapeutic target despite the need for further research to confirm its impact on structural fibrosis.

Sung-Ryeol Kim, Heejae Han, Jung-Won Park, Hye Jung Park, Jae-Hyun Lee2026-10-13

📄 medicine

Neonatal Hypothermia and its Associated Factors among Neonates Admitted to the Neonatal Intensive Care Unit in Western Ethiopia: A cross-sectional study

This cross-sectional study conducted in Western Ethiopia reveals a high prevalence (60.1%) of neonatal hypothermia among NICU admissions, identifying key associated factors such as lack of antenatal care, delayed breastfeeding initiation, obstetric complications, and specific neonatal characteristics like age under 24 hours, low birth weight, and underlying health problems.

Gudeta Berhanu, Mathewos Mekonnen, Ayele Tilahun, Endalu Guteta2026-10-13

📄 medicine

Effects of Plant-Derived Active Substances on Quality of Life and Chemotherapy-Induced Nausea and Vomiting in Cancer Patients Receiving Cisplatin-Based Chemotherapy: A Randomized Controlled Trial

This randomized controlled trial demonstrates that inhaling Cinnamomum camphora var. borneol essential oil (BEO) significantly reduces delayed vomiting severity and improves quality of life in cancer patients undergoing cisplatin-based chemotherapy, despite showing no significant effect on acute symptoms.

Ying Chen, Jinmei Chen, Jinmei Liang, Jie Yang, Jie Chen, Yanhui Zhang, Xinxin Xie2026-10-13

📄 medicine

Dementia and PDE5 inhibitors: A retrospective cohort study of veterans

This retrospective cohort study of over 878,000 U.S. male veterans with erectile dysfunction found that the use of PDE5 inhibitors was significantly associated with a reduced incidence and delayed onset of Alzheimer's, frontotemporal, and vascular dementia, suggesting a potential protective role for these medications that warrants further prospective investigation.

Vikas Singh, Rishi Sharma, Mukut Sharma, Thomas Wiegmann, Ram Sharma2026-10-13

📄 medicine

Determinants of Maternal Health Services Utilisation and Maternal Complications Among Puerperium Women at Muko Health Centre Iv, Rubanda District, Uganda

This cross-sectional study of 190 puerperium women at Muko Health Centre IV in Uganda identifies that while most mothers attend antenatal care, the utilization of maternal health services is significantly influenced by distance, transport costs, maternal age, marital status, and partner support, highlighting the need to address these barriers to reduce maternal complications.

Denis Atuheire, Mathew Igwe, Tamale Andrew, CHARLES IDEHEN2026-10-13

📄 medicine

The Many Faces of Salmonella: Atypical Extraintestinal Infections in a Tertiary Care Hospital in Pakistan

This case series from a tertiary care hospital in Pakistan describes five atypical extraintestinal Salmonella Typhi infections—including meningitis, thyroid abscess, spondylodiscitis, and hydatid cyst involvement—highlighting the importance of considering Salmonella in unusual focal infections within endemic settings and tailoring treatment based on culture and susceptibility testing.

Muhammad Shabir, Faiza zaheer, Faisal Hanif, Ibrar Hussain, Muhammad Huzifa, Taimoor Shahzad, Yumna Rubab, Amir Afzal kh (…)2026-10-13

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