📄 Category

medicine

4810 papers

📄 medicine

Is Anterior Reversed Proximal Humeral Locking Plate System (PHILOS) a Safe Alternative to Conventional Posterior Double Plating in Extra-Articular Distal Shaft Humeral Fractures: A Randomized Controlled Trial

This randomized controlled trial demonstrates that anterior reversed PHILOS plating is a safe and effective alternative to conventional posterior double plating for extra-articular distal humeral shaft fractures, offering comparable functional outcomes and union rates while significantly reducing operative time, surgical exposure, and the risk of nerve injury.

Sherif Hamdy Zawam, Mahmoud El-Desouky, Walid A Elnahal, Mostafa Ahmed Shawky2026-07-08
📄 medicine

An integrated single-cell transcriptomic pipeline identifies ZNF740/BRD3 and Cathepsin S as novel therapeutic targets in chronic active rim smoldering multiple sclerosis

This study presents an integrated single-cell transcriptomic pipeline that identifies ZNF740/BRD3, Cathepsin S, and DNMT1 as novel, blood-accessible therapeutic targets for treating chronic active rim smoldering multiple sclerosis through BET bromodomain inhibition, protease targeting, and epigenetic reprogramming, respectively.

John Goodman2026-07-08
📄 medicine

Prevalence and determinants of six-month virological failure among people living with HIV in Hubei, China: a population-based study

This population-based study in Hubei, China, found that the six-month virological failure rate among treatment-naïve people living with HIV was 6.8%, with female sex, higher baseline CD4 counts, and INSTI-based regimens identified as protective factors, while high baseline viral load and drug use-associated infection were significant risk factors.

Ke Hong, Dingyuan Zhao, Jie Zheng, Yurong Liu, Li Chen, Li Liu, Shixuan Qi, Qun Hu, Heng Tang, Ke Liang2026-07-08
📄 medicine

Acute Triggers and Long-Term Postpartum Outcomes of Diabetic Ketoacidosis in Pregnancy: A 7-Case Retrospective Series

This retrospective study of seven cases highlights that gestational diabetic ketoacidosis, often triggered by dexamethasone or pancreatitis, carries high fetal mortality risks and is frequently followed by persistent long-term metabolic complications, underscoring the necessity for prolonged multidisciplinary surveillance and strict glycemic management.

Ya-Li Yang, Qiao-Fang Yang, Xu-Fei Fan2026-07-08
📄 medicine

Reper artificial iris model C as an alternative treatment of traumatic aniridia and aphakia: a case series

This retrospective case series of four patients demonstrates that the Reper artificial iris prosthesis Model C, implanted via a three-point scleral fixation technique, is a safe and effective treatment for traumatic aniridia and aphakia, yielding significant improvements in visual function, symptom relief, and cosmetic satisfaction despite rare long-term complications.

Vasilios Batis, Sherif Ragaei Nabil, Augustina Grigaité, Yalda Sadeghi, Theodor Stappler, Kattayoon Kate Hashemi2026-07-08
📄 medicine

Liberal Versus Restrictive Red Blood Cell Transfusion Strategies in Leukemia: Protocol for a Pilot Randomized Controlled Trial Using Bleeding-Related Biomarker Endpoints

This protocol outlines a single-center pilot randomized controlled trial in Canada designed to assess the feasibility of a larger study and explore the biological effects of a liberal versus restrictive red blood cell transfusion strategy on bleeding-related biomarkers in patients with acute leukemia undergoing induction chemotherapy.

Dimpy Modi, Tobias Berg, Erin Jamula, Nancy Heddle, Dongyoung Kim, Patricia C. Liaw, Yang Liu, Melissa J. Parker, Geoff (…)2026-07-08
📄 medicine

Homocysteine Metabolic Dysregulation Drives Oral Submucous Fibrosis and is Rescued by 5-Methyltetrahydrofolate Intervention

This study demonstrates that homocysteine metabolic dysregulation drives oral submucous fibrosis through a p53-SMAD3 signaling pathway and that this pathological process can be effectively reversed by localized 5-methyltetrahydrofolate supplementation.

Shuangmeng Jia, Jiahe Han, Yishu Lu, Yingjia Zhu, Zixin Cai, Wuyan Lu, Haochang Liang, Zhibo Tan, Feiwu Kang, Jiefeng Hu (…)2026-07-08
📄 medicine

Dormitory Peer Effects on Physical FitnessDecline in Chinese Undergraduates：A Dual-Cohort Longitudinal Study with Hierarchical Linear Modeling

This dual-cohort longitudinal study of 4,157 Chinese undergraduates reveals that dormitory peer effects significantly shape physical fitness trajectories, with dormitory clustering emerging as a stronger predictor of senior-year fitness outcomes than BMI or sex, thereby highlighting the potential of targeted dormitory interventions during the freshman-sophomore transition to combat fitness decline.

Jing Gao, Dong Lin, Meiye Chen, Jianfeng Hu2026-07-08
📄 medicine

Development and Preliminary Psychometric Evaluation of the PQoL-34 Questionnaire for the Comprehensive Assessment of Quality of Life During Pregnancy and Family Preparedness for Childbirth: A Cross-Sectional Online Study in Southern Kazakhstan

This cross-sectional study in southern Kazakhstan developed and preliminarily validated the PQoL-34 questionnaire, demonstrating its high content validity, strong internal consistency, and convergent validity as a comprehensive tool for assessing quality of life during pregnancy and family readiness for childbirth.

Gulzira Dolanova¹, Gulzat Sarsenbayeva¹, Kulzhamila Kenessova¹2026-07-08