4810 papers
This case report describes a rare instance of spontaneous ovarian hyperstimulation syndrome in a post-thyroidectomy patient, caused by extreme TSH levels cross-activating FSH receptors via molecular mimicry, which was successfully resolved through levothyroxine replacement and supportive care without surgical intervention.
This study demonstrates that high L1CAM expression, detected via immunohistochemistry in a cohort of 233 patients, serves as a significant prognostic biomarker for poor overall and relapse-free survival in head and neck squamous cell carcinoma (HNSCC), particularly in early-stage and node-negative cases.
Based on a 2020 survey of 1,440 elderly diabetic patients in China, this study reveals a 46.67% depression prevalence and identifies that shorter sleep duration, lower income, poor self-rated health, pain, multiple comorbidities, memory concerns, and reduced daily activity ability significantly influence depression, with sleep duration acting as a mediating factor in these relationships.
This case report describes a rare instance of concurrent Factor XI and Factor XII deficiencies with suspected diminished Factor XIII activity in a 23-year-old Bangladeshi male, highlighting the importance of systematically investigating all intrinsic pathway factors in patients with prolonged aPTT and mild bleeding symptoms.
This longitudinal birth cohort study found that while nearly all children were exposed to sugar within their first year and nearly half had dental caries by age 48 months, the timing or frequency of early sugar introduction was not statistically associated with caries experience at that age.
This post hoc analysis of the EAST trial found that early combined antiplatelet treatment with clopidogrel and aspirin following intravenous thrombolysis did not significantly improve 90-day functional outcomes in patients with acute minor ischemic stroke, regardless of whether they had large artery atherosclerosis or not.
This prospective study demonstrates that partial breast proton beam therapy without surgical resection is a safe and effective alternative for low-risk early-stage breast cancer, achieving five-year local control with manageable toxicity in a cohort of 11 patients.
This longitudinal study across China, the US, and the UK demonstrates that higher cardiometabolic disease burden, specific disease types like cardiovascular disease, and low socioeconomic status independently increase the risk of psychological-cognitive comorbidity in middle-aged and older adults, highlighting the need for integrated medical and socioeconomic interventions.
This machine learning study utilizing the MIMIC-IV database demonstrates that the hemoglobin-to-red cell distribution width ratio (HRR) is a superior, nonlinear predictor of type 2 diabetic kidney disease risk compared to hemoglobin or RDW alone, with an optimal risk threshold of 6.9492 identified via the LightGBM algorithm.
This prospective observational study demonstrates that serial transthoracic echocardiography can detect significant reductions in stroke volume prior to the onset of clinically apparent hypotension in women undergoing elective cesarean delivery under spinal anesthesia, establishing its potential as an early warning tool for hemodynamic monitoring.