4810 papers
This study demonstrates that while the Mayo Score effectively reflects disease extent in ulcerative colitis, it fails to predict the presence of premalignant colorectal lesions or extraintestinal manifestations, suggesting it measures current severity rather than long-term complications.
This study presents the first noninvasive murine model of hyperthermic intraperitoneal chemotherapy (HIPEC) for ovarian cancer, demonstrating that external abdominal heating combined with chemotherapy significantly attenuates tumor growth, delays ascites development, and extends survival compared to normothermic treatment, thereby enabling mechanistic studies to optimize HIPEC protocols.
This study of over 22,000 Norwegian adolescents reveals that early-life multimorbidity is significantly associated with reduced health-related quality of life, particularly in mental wellbeing, with the negative impact appearing to be primarily additive based on the number of conditions rather than specific comorbidity patterns.
A 12-week supervised exercise intervention in patients with COPD significantly improved peripheral airway function as measured by impulse oscillometry and enhanced exercise capacity and symptoms, despite showing minimal changes in traditional spirometry and lung volumes.
This retrospective cohort study developed and internally validated a simple nomogram using age, sex, HbA1c, and the ApoB/ApoA1 ratio to effectively predict carotid plaque risk in elderly general practice patients, offering a practical tool for individualized risk stratification and clinical decision-making.
This longitudinal study of 68 children with autism in a high-resource community reveals that most received intensive, multidisciplinary public services with equitable access across income levels, though service intensity in preschool was predicted by nonverbal developmental quotient rather than socioeconomic status.
In a retrospective study of colon cancer patients, mucinous adenocarcinomas were found to be more frequently right-sided and poorly differentiated than classic adenocarcinomas, yet they were not independently associated with deeper tumor invasion or nodal metastasis after adjusting for confounding factors.
This research note demonstrates the technical feasibility of using nominal 0.4-T gadoxetic acid-enhanced hepatobiliary-phase MRI with image-domain deep-learning reconstruction to visualize hepatocellular carcinoma in three mice, though it confirms no improvement in lesion detection or diagnostic performance compared to standard imaging.
This national survey of 49 Chinese dental schools reveals that while dentoalveolar surgery education has established a framework centered on tooth extraction and local anesthesia, it faces significant challenges including a lack of course independence, inconsistent teaching hours, insufficient training in complex procedures, limited adoption of interactive digital tools, and an overreliance on theoretical assessment.
This systematic review of 103 studies reveals that inconsistent definitions, reporting methods, and unaccounted contextual factors like ward design and staffing levels undermine the validity of current inpatient fall metrics, necessitating a shift toward a systems perspective and Human Factors methodologies to improve patient safety.