📄 medicine

Central Line-Associated Bloodstream Infection in Hospitalized Children: A Retrospective Cohort Study of Risk, Mortality, and Antimicrobial Resistance

This retrospective cohort study of hospitalized children in Tehran reveals that central line-associated bloodstream infections are common and linked to high mortality and multidrug resistance, with specific risks associated with cardiac ICU placement, femoral catheter use, and thrombocytopenia.

Hamed Tabasizadeh, Babak Pourakbari, Maryam Sotudeh, Reihaneh Hosseinpour Sadeghi, Mohammad Farahmand, Setareh Mamishi2026-07-07
📄 medicine

Long-term cardiovascular adverse events in liver transplant recipients with over 10 years of survival: incidence, temporal pattern and preoperative risk factors

This study of long-term liver transplant survivors reveals that preoperative hypertension is the sole independent predictor of major adverse cardiovascular events, which continue to occur significantly beyond the 10-year post-transplant mark, underscoring the need for lifelong cardiovascular surveillance and blood pressure management.

Hui-kuan Gao, Fei Hou, Lin Wei, Wei Qu, Zhi-gui Zeng, Zhi-jun Zhu, Hao-feng Xiong, Li-ying Sun2026-07-07
📄 medicine

Social Media Utilisation to Understand the Journey and Unmet Needs of Patients With Parkinson's Disease in the Philippines

This phenomenological study analyzes social media narratives from Filipino Parkinson's disease patients and caregivers to reveal a journey defined by severe economic hardship, diagnostic delays, and geographic disparities, highlighting the urgent need for improved medication access, multidisciplinary care, and government support in the Philippines.

Charity Joy E. Limpiado, Gerard Saranza2026-07-07
📄 medicine

Clinical and Radiographic Outcomes of Second Molars with External Root Resorption Following Impacted Third Molar Removal: A Retrospective CBCT-Based Cohort Study

This retrospective CBCT-based cohort study demonstrates that while impacted third molar extraction alone effectively halts external root resorption and preserves pulp sensibility in affected second molars, adjunctive guided bone regeneration significantly enhances distal alveolar bone regeneration compared to extraction alone.

Baocheng Yao, Shiyu Qiu, Chengyi Wang, Qiao Ling, Ning Ma2026-07-07
📄 medicine

The FFA/ApoA1 ratio is an independent predictor of overall survival in nonobese patients with colon cancer: A retrospective study

This retrospective study demonstrates that the free fatty acid-to-apolipoprotein A1 (FFA/ApoA1) ratio is a significant independent predictor of overall survival specifically in nonobese patients with colon cancer, exhibiting superior prognostic value in this subgroup compared to obese patients or those with rectal cancer.

Bin Zhu, Dan Wu, Jin Liu, Zhen Lin, Qingzhu Zheng, Yingping Cao2026-07-07
📄 medicine

Dissociation of Presynaptic and Postsynaptic Dopaminergic Associations with Microstructural Alterations in Parkinson’s Disease

This study reveals a spatial dissociation in Parkinson's disease where subcortical microstructural alterations are strongly linked to presynaptic dopaminergic terminal loss, while cortical changes exhibit consistent, neuroinflammation-related associations with dopaminergic markers.

Marta M. Pokotylo, Norman Griebner, Luzian Weske, Martin Göttlich, Jan Uter, Julia Henkel, Norbert Brüggemann, Jannik Pr (…)2026-07-07
📄 medicine

An orally active apelin receptor agonist improves Alzheimer’s disease pathology and cognitive functions by restoring microglial metabolism

The orally active apelin receptor agonist CMF-019 crosses the blood-brain barrier to restore microglial metabolism, enhance amyloid-β clearance, and improve cognitive functions in Alzheimer's disease mouse models.

Oscar Ka-Fai Ma, Luiseach Gillespie, Peilin Wang, Carlton Wong, Guang-Jei Zhou, James Bagnall, Kenneth Mei Yee Leung, As (…)2026-07-07
📄 medicine

Cross-cultural Validation of the SOS-scale for Iatrogenic Withdrawal Syndrome in Brazilian PICUs: Comparison with the WAT-1

This study validates the Brazilian Portuguese version of the SOS-scale as a reliable and highly accurate tool for detecting iatrogenic withdrawal syndrome in critically ill children, demonstrating strong correlation with the WAT-1 and establishing an optimal diagnostic cut-off score of ≥ 4.

Kátia Lins Curtinaz, Kassiely Klein, Marcela Weber, Miriam Neis, Paulo Carvalho, Taís Sica da Rocha2026-07-07