4814 papers
This retrospective cohort study of 395 hospitalized COVID-19 patients reveals that elderly males face the highest risk of severe disease and multi-organ complications due to a synergistic effect of age- and sex-related immune dysregulation, underscoring the critical need for tailored therapeutic strategies rather than a one-size-fits-all approach.
This mixed-methods study of general practitioners in private clinics in Eastern Indonesia reveals that perceived medication error prevention is primarily driven by effective digital workflow alignment, which is significantly influenced by AI readiness, digital competency, EMR system quality, and peer influence, while remaining unaffected by capitation-based financing regulations.
This case report describes a rare instance of a pediatric cerebellar pilocytic astrocytoma with a high Ki-67 index and KIAA1549-BRAF fusion that exhibited exceptionally rapid recurrence despite surgical resection, but achieved durable disease control following the initiation of targeted trametinib and dabrafenib therapy.
This case report describes the successful treatment of a rare pseudoaneurysm of the mitral-aortic intervalvular fibrosa in a 42-year-old woman, which developed two years after aortic valve replacement with Y-incision root enlargement, through a Bentall procedure following a diagnosis complicated by mechanical valve artifacts and ineffective antibiotic therapy for Staphylococcus capitis bacteremia.
This study reveals that capillary-associated macrophages (CAMs) promote lung cancer chemotherapy resistance by increasing vascular permeability via the VEGF/PI3K/Akt pathway, and demonstrates that depleting CAMs or blocking this signaling axis significantly enhances drug delivery and therapeutic efficacy.
This systematic review and meta-analysis of 68 studies reveals that while existing coronary artery disease risk prediction models show moderate discriminative ability, their high risk of bias and heterogeneity limit clinical applicability, suggesting a need for future research focused on specific subgroups and machine learning-based models.
This cross-sectional study of 180 hemodialysis patients reveals a high prevalence (68.9%) of CKD-MBD, identifying poor adherence to phosphate binders and vitamin D deficiency as the strongest modifiable risk factors associated with the disorder.
This study reveals that lactoferrin signals in cerebrospinal fluid and plasma are assay-, compartment-, and network-context dependent rather than interchangeable or standalone biomarkers for Alzheimer's disease pathology.
This study reveals that parents of children with ADHD show low to moderate agreement between their self-reports and informant reports regarding ADHD symptoms and executive functioning, suggesting that such discrepancies likely stem from genuine differences in perspective rather than simple self-report bias.
This UK Biobank cohort study of over 500,000 participants demonstrates that lower grip strength and slower walking pace are independently associated with an increased risk of incident degenerative cervical myelopathy, offering modest risk enrichment for early clinical suspicion but insufficient standalone value for screening or replacing standard neurological evaluation.