4814 papers
This qualitative interview study of 19 trialists identifies three critical considerations for adapting complex interventions to remote delivery during clinical trials: the need to reconfigure costs and resources, the management of implementation challenges affecting engagement and fidelity, and the adaptation of safety management protocols.
This interpretive phenomenological study of 17 older adults in suburban Kerala, India, reveals that hospital service utilization is shaped by a complex interplay of individual vulnerabilities, interpersonal dynamics, community barriers, healthcare system deficiencies, and policy gaps, underscoring the urgent need for age-friendly, person-centered care reforms.
This retrospective real-world study from Xuanwei, China, demonstrates that NSCLC patients in this high-incidence region achieved significantly higher disease control rates with camrelizumab and sintilimab compared to non-Xuanwei patients, suggesting unique regional factors may influence the efficacy of specific PD-1 inhibitors.
This study identifies a distinct serum metabolomic signature in autoimmune gastritis characterized by acylcarnitine and amino acid alterations linked to mitochondrial dysfunction, establishing the C2/C0 ratio as a promising non-invasive diagnostic biomarker.
This multicenter cross-sectional study of 634 neonates in China found that feeding patterns are significantly associated with sleep duration and nighttime awakenings, with formula-fed infants exhibiting longer daytime sleep but shorter nighttime sleep and more frequent awakenings compared to exclusively breastfed infants.
This study validates the ORPI-26 survey as a reliable tool for assessing residency graduates' self-perceived preparedness in Oman, revealing high overall readiness but identifying specific deficits in systems-based practice, legal/risk management, and research planning that warrant targeted curricular improvements.
This prospective comparative study of 74 patients found that while closed endonasal septoplasty offers shorter operative times and less early postoperative pain, open approach septoplasty yields superior quality of life outcomes and fewer complications at one month, particularly for complex septal deviations.
This 2024 mixed-methods study in Mattu Town, Ethiopia, reveals that despite high latrine coverage and disease knowledge, critical deficiencies in water quality, handwashing facilities, and waste management persist, necessitating a shift from general awareness campaigns to targeted infrastructure improvements and specific behavioral interventions.
This study synthesizes 25 best pieces of evidence from 15 high-quality sources to provide a comprehensive, evidence-based framework for postoperative pain management in elderly patients with hip fragility fractures, covering assessment, pharmacological and non-pharmacological interventions, and health education.
This cross-sectional study of 385 Brazilian medical students reveals that while self-assessed palliative care competencies generally improve throughout medical training, significant gaps remain in care coordination, teamwork, and self-awareness, highlighting the urgent need to strengthen palliative care education in Brazil.