📄 medicine

Efficacy, Safety, and Certainty of Evidence for Systemic Antineoplastic Therapies in Treatment-resistant Adult Malignancies: A Systematic Review, Exploratory Meta-analysis, and Grade Assessment

This systematic review and exploratory meta-analysis of 18 randomized clinical trials (2021–2026) concludes that while selected systemic antineoplastic therapies offer clinically meaningful survival and response benefits for adults with treatment-resistant malignancies, high-certainty evidence is concentrated in specific therapeutic contexts and pooled estimates must be interpreted cautiously due to substantial heterogeneity.

Mayky Sousa Rodrigues, Luid Alberto Silva, Carlos Eduardo de Moura Silva2026-07-07
📄 medicine

Effect of Olive Oil Back Massage on Selected Fetomaternal Parameters and Maternal Satisfaction Among Primigravid Women During the First Stage of Labour: A Quasi-Experimental Study

This quasi-experimental study demonstrates that olive oil back massage significantly improves uterine contraction characteristics and yields high maternal satisfaction among primigravid women during the first stage of labour, while maintaining stable fetal and maternal physiological parameters.

Mekala Moorthy2026-07-07
📄 medicine

Work-Related Musculoskeletal Disorders among Public Bus Drivers in Kerala: A Cross-Sectional Study Linking Ergonomic Strain to Road Safety Risk

This cross-sectional study of 405 Kerala bus drivers reveals an alarmingly high prevalence of work-related musculoskeletal disorders, particularly in the lumbar region, which is significantly associated with excessive daytime sleepiness, shorter sleep duration, and excessive working hours, thereby linking ergonomic strain to increased road safety risks.

ARUN CHAND, A B Bhasi2026-07-07
📄 medicine

Structural Findings Transfer, Texture Findings Do Not: An Adaptation Ladder for Cross-Center Dental Diagnosis

This paper demonstrates that while a safety-enforced adaptation framework can successfully transfer structural dental pathology detection across clinical centers using minimal resources, it fails to bridge the domain gap for texture-based findings like caries, suggesting that safe cross-center deployment requires adapting to transferable features while formally refusing non-transferable ones rather than pursuing a universal model.

Prof. Ayman Elnashar, Norsin Elnashar, Prof. Ahmed Elemam2026-07-07
📄 medicine

Hate speech and rage bait on social media in Greece: Prevalence and association with mental health

This cross-sectional study conducted in Greece reveals that hate speech and rage bait are highly prevalent on social media and are independently associated with increased anxiety, depression, and loneliness among users, whether they experience them as victims, bystanders, or through engagement with such content.

Petros Galanis, Aglaia Katsiroumpa, Panagiota Peleka, Antigoni Kolisiati, Ioannis Moisoglou2026-07-07
📄 medicine

Rethinking Pain: A Systems Change Model for Integrating the VCSE and NHS to provide place-based community pain support

This paper presents a Theory of Change-based systems model for integrating the NHS and VCSE sectors to deliver place-based, whole-person chronic pain support in Bradford, aiming to shift care from biomedical interventions to community resources, reduce health inequalities, and alleviate NHS pressures.

Kate Thompson, Shahzad Jamil, Kerry Page, Ghazala Tabasam, James Woodall, Mark I. Johnson2026-07-07
📄 medicine

The Social Determinants of Health and Perioperative Outcomes by Surgical Specialty: A Scoping Review

This scoping review of 167 articles synthesizes existing evidence on the relationship between social determinants of health and perioperative outcomes, revealing strong links between socioeconomic status and mortality as well as insurance status and hospital utilization, while highlighting significant gaps in research regarding language, health literacy, and other demographic factors.

Bridget Lally, Jessica Cao, Jeremy Sullivan, Kelly McQueen2026-07-07
📄 medicine

Mapping EQ-5D-3L Utility Values from the UK to EQ-5D-5L for Type 2 Diabetes Patients in Saudi Arabia

This study develops a robust hybrid heteroskedastic mapping method to convert UK-based EQ-5D-3L utility values into Saudi Arabia-specific EQ-5D-5L values for Type 2 Diabetes patients, demonstrating significant variations in health utility based on the presence of complications to support accurate local economic evaluations.

Hajer AlMudaiheem, Ahmed Al Jedai, Mohamed Al Shennawi, Mohammed Alluhidan, Wejdan Aburas, Mohamed Khedr, Pratik Dhopte (…)2026-07-07
📄 medicine

Clinical Outcomes of Kidney Re-transplantation in Elderly vs. Young Recipients: A Nationwide Cohort Study from the Korean Organ Transplantation Registry

This nationwide cohort study from the Korean Organ Transplantation Registry reveals that while elderly kidney re-transplant recipients achieve graft survival rates comparable to younger recipients, they face significantly higher risks of infection and mortality driven by comorbidities, highlighting the need for tailored peri- and post-transplant care.

Hanbi Lee, Hye Eun Yoon, Sang Hun Eum, Young Joo Kwon, Ji Yoon Choi, Jaeseok Yang, Myoung Soo Kim, Byung Ha Chung2026-07-07