📄 medicine

Investigation of Plasmodium Species in Donated Stored Blood Units at Ndola Teaching Hospital, Ndola, Copperbelt Province, Zambia

This study reveals that 8% of ready-to-transfuse blood units at Ndola Teaching Hospital in Zambia contain *Plasmodium* parasites, predominantly *P. falciparum*, highlighting a critical, unmonitored risk of transfusion-transmitted malaria that necessitates the inclusion of malaria screening in national blood safety protocols.

Patrick Loti, Frank Chisulo K., Agness Chama, Alick Mwambungu, Karen Chanda, Mazuba Banda2026-07-05
📄 medicine

Clinical Validation of Orthodontic Oral Health Literacy and Behavior Tools (OHL-Ortho & OHB): A Cross-Sectional Assessment Using CPITN, OHI-S and Objective Knowledge Measures

This study provides the first clinical validation of the newly developed OHL-Ortho and OHB instruments, demonstrating their strong reliability and significant ability to predict factual knowledge, oral hygiene behaviors, and clinical periodontal outcomes in adult patients undergoing fixed orthodontic treatment.

Muhammad Raif Ilyas, Syed Muhammad Ali Gilani, Muhammad Mughni, Mubassar Fida, Rashna Hoshang Sukhia2026-07-05
📄 medicine

Reliability and Clinical Accuracy of ChatGPT in Post-FESS Counselling: A Multi-Reviewer Evaluation.

This study evaluates ChatGPT's performance in generating postoperative FESS counseling, finding that while it offers acceptable reliability for standardized guidance with high inter-rater agreement on appropriateness, it exhibits limitations in contextual accuracy and readability that necessitate clinician oversight.

PARAMITA DEBNATH, MISBAHUL HAQUE, PRAKRITI SAMADDAR, NEHA YADAV2026-07-05
📄 medicine

Biofeedback using electrical impedance tomography during inhalation therapy for chronic obstructive lung disease – a pilot study

This pilot study demonstrates that while biofeedback-guided inhalation using electrical impedance tomography did not improve obstructive lung parameters (FEV1) in COPD patients, it significantly reduced hyperinflation (FRC) compared to standard inhalation, suggesting potential benefits for inhalation technique and lung volume management.

Svenja Stolz, Rosa Meyer, Torben Rixecker, Robert Bals, Philipp M. Lepper, André Becker2026-07-05
📄 medicine

Association between atherogenic index of plasma and mortality of patients with sepsis: Evidence from a large population-based study based on the MIMIC-IV database and EICU-CRD database

This large population-based study utilizing MIMIC-IV and EICU-CRD databases reveals that a higher atherogenic index of plasma (AIP) is independently and non-linearly associated with increased 168-hour mortality in sepsis patients, with lactate metabolism and organ dysfunction serving as key mediating mechanisms.

Juan Wang, Yanfang Shang, Limeng Zhang, Yan Wang, Haibo Ge2026-07-05
📄 medicine

Fibrillary Glomerulonephritis: Clinicopathologic Features and Outcomes

This retrospective study of 30 patients with fibrillary glomerulonephritis highlights the disease's heterogeneous clinical presentation and generally poor kidney outcomes, with over half progressing to end-stage kidney disease and higher serum creatinine at biopsy identified as the sole predictor of progression.

Hanny Sawaf, Omar Osman, Abdul Hamid Borghol, Tariku T. Gudura, Leal Herlitz, Ali Mehdi, Scott Cohen, Surafel K. Gebrese (…)2026-07-05
📄 medicine

Case report Recurrent dialysis-dependent acute kidney injury caused by distinct tubulointerstitial mechanisms with complete recovery

This case report describes a rare instance of a patient experiencing two separate, life-threatening episodes of dialysis-dependent acute kidney injury caused by distinct mechanisms (gentamicin-induced toxic tubular necrosis and hantavirus-induced immune-mediated interstitial nephritis) over a 12-year period, both of which resulted in complete renal recovery without progression to chronic kidney disease.

Balázs Sági, Attila Böröcz, Viktória Bekő, Botond Csiky, Tibor József Kovács2026-07-05
📄 medicine

From different backgrounds to homogeneity in cardiopulmonary resuscitation knowledge: a pre-post study on instructor-led training to healthcare professionals, medical students and laypeople

This pre-post study demonstrates that instructor-led Basic Life Support training significantly improves CPR knowledge across healthcare professionals, medical students, and laypeople, effectively equalizing theoretical scores regardless of prior background while revealing distinct learning patterns such as cognitive interference for experts and a theoretical-practical gap for laypeople.

Abel Nicolau, Inês Jorge, Inês Lourenço, Gustavo Mendes, Cristina Granja2026-07-05
📄 medicine

Biomechanical Study of a Novel External Fixation Frame Controlling Postoperative Loss of Reduction in Thoracolumbar Fractures: Finite Element Analysis

This finite element analysis demonstrates that a novel Micro-Adjustable External Fixation (MAEF) device provides superior biomechanical stability and stress distribution compared to traditional percutaneous short-segment intermediate screw fixation (PSISF), potentially reducing postoperative complications and accelerating fracture healing in thoracolumbar fractures.

Hui Guo, Jiahao Feng, Yanyan Xue, Kun Wang, Ming Hao, Shaobo Nie2026-07-05
📄 medicine

Dysregulation of the inside-out signaling pathway in CNS-infiltrated pediatric T-cell acute lymphoblastic leukemia

This study identifies the dysregulation of the TCR-mediated inside-out signaling pathway, particularly involving the adaptor protein SKAP1, as a key mechanism driving central nervous system infiltration and relapse in pediatric T-cell acute lymphoblastic leukemia.

Frida Holm, Sabina Enlund, Konstantinos Papadakis, Jacob Short, Katja Pokrovskaja Tamm, Ola Hermanson, Anna Nilsson, Qin (…)2026-07-05