medicine papers | Gist.Science

Barriers and Facilitators to Implementing Home-Based Palliative Care in a Resource-Constrained Setting: A Qualitative Descriptive Study from the West Bank, Palestine

This qualitative descriptive study from the West Bank identifies key barriers (such as workforce shortages, movement restrictions, and misconceptions) and facilitators (including psychosocial benefits and multidisciplinary teamwork) to implementing home-based palliative care, concluding that successful adoption requires trained teams, coordinated referral pathways, and policy support.

Amin Dahdolan, Hanan Sac-Hazboun2026-10-22

📄 medicine

Methadone for intractable pain associated with the neoplastic brachial plexopathy: a retrospective analysis of 23 patients

This retrospective analysis of 23 patients demonstrates that methadone is an effective and safe treatment option for reducing intractable pain associated with neoplastic brachial plexopathy, significantly lowering pain intensity with minimal adverse effects.

Tetsumi Sato, Shigeki Ono, Taiichi Kawamura, Akira Fukutomi, Yoshiko Kamo, Akane Wakabayashi, Takamori Miyaguchi, Tetsu (…)2026-10-22

📄 medicine

Menopause and accelerated decline in the physical component of intrinsic capacity in Chinese women: a longitudinal cohort study

This longitudinal cohort study of Chinese women demonstrates that the menopausal transition is associated with an accelerated annual decline in the physical component of intrinsic capacity, a rate of deterioration that further increases with the number of years elapsed since menopause.

Lin Yang, SenJun Deng2026-10-22

📄 medicine

A Dual-Track Knowledge Graph for Evidence-Based Pediatric Medication Management in Neurological Disorders: Implications for Rational Drug Use and Public Health Governance

This study proposes a dual-track knowledge graph framework that integrates clinical guideline evidence with semantic-derived associations to systematically organize pediatric neurological medication data, thereby identifying critical resource gaps and providing empirical support for optimizing evidence-based drug use and public health governance.

QiuYue Chen, Qian Zhuang2026-10-22

📄 medicine

Prevalence of dementia and mild cognitive impairment in Morocco: A population-based study

This nationwide telephone survey of 1,662 Moroccan adults aged 60 and older reveals a weighted prevalence of 11.6% for dementia and 23.6% for mild cognitive impairment, highlighting a substantial cognitive health burden across the country's 12 administrative regions.

ABDELILAH BENOUAJJIT, ZOUHAYR SOUIRTI2026-10-22

📄 medicine

Effectiveness evaluation of a comprehensive HIV intervention based on Internet and community engagement among MSM populations in China: a prospective multicenter cluster randomized controlled trial

This prospective multicenter cluster randomized controlled trial in China demonstrates that a comprehensive HIV intervention integrating Internet-based appointment platforms with offline community screening significantly increased testing frequency and reduced self-assessed risk scores among men who have sex with men (MSM).

Zhen Jiang, Chen-Long Lv, Fan Lv, Li-Li Dai, Wei Ma, Jie Wu, Wei Luo, Kangmai Liu, Keming Rou, Zhen Xie, Zihuang Chen, F (…)2026-10-22

📄 medicine

Intraoperative Radiotherapy with INTRABEAM® in Early-Stage breast Cancer patients: a 10-Year Monocentric experience

This 10-year retrospective study of 247 early-stage breast cancer patients demonstrates that intraoperative radiotherapy with INTRABEAM® offers favorable long-term oncological outcomes and acceptable toxicity, serving as a convenient and well-tolerated alternative to whole-breast irradiation, particularly for elderly or frail populations.

Constance HUCK, Anna VIALARD, Carine BELLERA, Imed TALEB, Mathilde MAIRE, Jerôme CARON, Sophie AURIOL, Anne De La ROCHEF (…)2026-10-22

📄 medicine

Risk factors for diabetic kidney disease and the interaction between glycemic variability and systolic blood pressure in young overweight/obese patients with type 2 diabetes: a retrospective cross-sectional study

This retrospective study of 3,162 young overweight or obese patients with type 2 diabetes identifies elevated glycemic variability as a core independent risk factor for diabetic kidney disease that exhibits a significant multiplicative interaction with systolic blood pressure, suggesting that high blood pressure amplifies the kidney injury caused by glucose fluctuations.

Manli Yang¹, Chang Liu², Peng Liu³, Fangfang Liu³, Huiping Yuan¹, Mingxia Gao⁴, Zhumin Jia⁵2026-10-22

📄 medicine

Intraperitoneal thermal priming followed by intravenous liposomal or free cisplatin in a murine ovarian cancer peritoneal dissemination model

In a murine model of ovarian cancer peritoneal dissemination, intraperitoneal thermal priming at 43°C followed by intravenous liposomal cisplatin demonstrated superior antitumor efficacy, higher tumor platinum accumulation, and reduced toxicity compared to free cisplatin.

Shiyu Zhang, Chang Zhou, Caiyao Chen, Jing Liang, Bin Ling2026-10-22

📄 medicine

Transgastric Natural Orifice Transluminal Endoscopic Surgery for Adhesiolysis: A Study in a Beagle Model of Adhesive Intestinal Obstruction

This study demonstrates that transgastric natural orifice transluminal endoscopic surgery (TG-NOTES) is a safe, effective, and minimally invasive technique for treating adhesive intestinal obstruction in a beagle model, offering scarless recovery with low complication rates and no adhesion recurrence at six months.

Wen Lin, Chuan-Shen Jiang, Xin-Yi Zheng, Dong-Gui Hong, Long-Ping Chen, Yan Zhuang, Han Lin, Wen Wang, Xiao-Jian He, Da- (…)2026-10-22

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