📄 medicine

The EXPOS Score for Predicting First-Pass Failure During Video Laryngoscopic Intubation in Critically Ill Adults: Development and External Validation

This study developed and externally validated the EXPOS Score, a six-variable bedside tool that effectively predicts the risk of first-pass failure during video laryngoscopic intubation in critically ill adults.

Luc Desmedt, Jonathan D. Casey, Vincenzo Russotto, Matthew E. Prekker, Stacy A. Trent, Matthew W. Semler, Anaïs Curtiaud (…)2026-10-22
📄 medicine

Impact of Right Ventricular Pacing Burden on Left Ventricular Deformation and Rotational Mechanics: A Cohort Study

This prospective cohort study demonstrates that a right ventricular pacing burden exceeding 40% is independently associated with early, subclinical impairment of left ventricular global longitudinal strain in patients with structurally normal hearts, a change detectable by speckle-tracking echocardiography before conventional ejection fraction declines.

Rashmi K.S, Jyothi Samanth, Umesh Pai, Padmakumar R, Mukund A Prabhu, Tom Devasia, Reshma Nayak, Shubha Srinivas, Karthi (…)2026-10-22
📄 medicine

Diagnostic Accuracy of Reported Hearing Difficulty for Identifying Pure-Tone Audiometry Threshold Elevation in Children and Adolescents With Sickle Cell Disease in Eastern Uganda: A Cross-Sectional Secondary Analysis

In children and adolescents with sickle cell disease in Eastern Uganda, self- or caregiver-reported hearing difficulty demonstrates very low sensitivity and minimal agreement with objective pure-tone audiometry findings, indicating that symptom enquiry alone is insufficient for identifying hearing loss and should not preclude routine audiologic evaluation.

Christine Adoch, Kevin Achiro, Amone Derick³, Otto Julius⁴, Owiny Augustine Okejomoe2026-10-22
📄 medicine

Influence of CT Tube Replacement and System Parameter Update on Reconstructed CT Values and Electron Density Conversion Curves in Radiotherapy Treatment Planning Systems

This study demonstrates that while CT tube replacement and system parameter updates do not affect conventional image quality indicators, they induce significant, material-dependent Hounsfield Unit drifts that necessitate re-measuring multi-material baselines and reconstructing electron density conversion curves to ensure accurate radiotherapy dose calculations.

Chunxiang Chen, Yangyang Sun, Guijiao Xie, Jianwei Yang, Yuting Ye2026-10-22
📄 medicine

Sleep quality, chronotype, and psychological distress in adults with chronic conditions: independent associations and nonlinear sleep-quality gradients

This cross-sectional study of adults with chronic conditions in Sichuan, China, found that poorer sleep quality and a higher burden of chronic conditions are consistently and independently associated with increased psychological distress, while morningness exhibits a weaker, less robust inverse relationship.

Yao Luo, Yuanwei Lu, SiYi Xiao, Xiong Ke2026-10-22
📄 medicine

Seborrheic Dermatitis Exhibits Only a Modest Systemic Inflammatory Signature: A Retrospective Case-Control Study

This retrospective case-control study concludes that while seborrheic dermatitis exhibits a modest systemic inflammatory signature detectable by CRP and ESR, blood count-derived indices show poor discriminatory power and lack association with disease severity, rendering them unsuitable for clinical assessment of the condition.

Tuğba Kevser Uzunçakmak, Yusuf Demir, Ömer Faruk Tolun, Muazzez Çiğdem Oba, Zekayi Kutlubay, Burhan Engin2026-10-22
📄 medicine

Comparative Effects of Bariatric Surgery Techniques on Cardiometabolic Indices: A Cohort Study in Shiraz, Iran

This retrospective cohort study in Shiraz, Iran, found that while sleeve gastrectomy and Roux-en-Y gastric bypass achieved comparable weight loss and improvements in most cardiometabolic indices over 12 months, RYGB resulted in a significantly greater reduction in the lipoprotein combine index (LCI).

Babak Hosseini, Masoud Amini, Ladan Aghakhani, Meisam Alipour, Nader Moeinvaziri, Neda Haghighat2026-10-22
📄 medicine

Parenteral Nutrition, Microplastic Burden, and Bronchopulmonary Dysplasia Severity in Preterm Infants: A Prospective Observational Study

This prospective observational study reveals that in preterm infants with bronchopulmonary dysplasia, the duration of parenteral nutrition is strongly correlated with circulating microplastic burden, which is independently associated with increased disease severity, suggesting microplastics may act as a mediator linking prolonged plastic-based infusion systems to worse pulmonary outcomes.

Zhenyu Liang, Debo Xu, Lingling Chen, Lin Li, Huiyi Li, Qiaohuan Yang, Qiong Meng, Wei Zhou2026-10-22
📄 medicine

Comparing OHRQoL between pre- and post-Comprehensive Care Cohorts with post-CCC Clinical and Radiographic Evaluation at Pharos University

This study at Pharos University demonstrates that patients who completed comprehensive case care reported significantly better oral health-related quality of life and favorable clinical outcomes compared to those awaiting treatment, highlighting the positive impact of multidisciplinary dental care on both clinical health and patient well-being.

Maha Ibrahim Adel, Engy Hassan Khamis, Shahd Gelany, Engy Hassan Fathy, Lujain Reda, Esraa Bishr2026-10-22
📄 medicine

Reproducible and Sustained Response to Prolonged-Release Fampridine in Severe GAA-FGF14 Ataxia: A Longitudinal Single-Patient Observation

This longitudinal single-patient study demonstrates that prolonged-release fampridine induces a marked, reproducible, and sustained multidomain improvement in a severely disabled patient with GAA-FGF14 ataxia, as confirmed by a rigorous OFF–ON–OFF–ON dechallenge/rechallenge design and 52 weeks of continuous treatment.

Claudio Marcello Solaro, Novella Pretti2026-10-22