📄 Category

medicine

3171 papers

📄 medicine

The mask efficacy controversy reconsidered: a systematic review using mechanism-informed narrative synthesis

This systematic review employs a Mechanism-Informed Narrative Synthesis (MINS) to demonstrate that apparent inconsistencies in face mask efficacy research are largely explained by contextual factors and methodological limitations, ultimately concluding that well-fitting masks worn consistently during relevant exposure periods effectively reduce respiratory disease transmission.

Trisha Greenhalgh, Sahanika Ratnayake, Rebecca Helm, Luana Poliseli, Jon Williamson, Jemma Houghton2026-07-17
📄 medicine

 Medicaid Expansion and Implementation of Medication for Opioid Use Disorder Treatment Planning in U.S. Publicly Funded Specialty Treatment Systems

This retrospective study of over 10 million admissions found that while Medicaid expansion was associated with a short-term increase in documented medication for opioid use disorder (MOUD) planning within publicly funded treatment systems, the effects were not sustained and significant disparities persisted among vulnerable populations, suggesting that insurance expansion alone is insufficient to ensure equitable access to evidence-based treatment.

Suparna Das, Kerry Green2026-07-17
📄 medicine

Morphometric characterization of the left colonic dissection three (D3) area using preoperative 3D vascular reconstruction with cadaveric validation: implications for individualized central lymphadenectomy

This study utilizes preoperative 3D vascular reconstruction and cadaveric validation to morphometrically characterize the variable left colonic D3 dissection area, demonstrating that its size correlates with inferior mesenteric artery segment length and supporting the use of 3D imaging for planning individualized central lymphadenectomy in left-sided colon cancer.

Vladimir Zivanovic, Dejan Ignjatovic, Javier Armando Luzon, Bojan Vladimir Stimec2026-07-17
📄 medicine

Hidden Functional Decline: How Conversational Voice AI Detects Early Mobility and ADL Impairment in Older Adults with High Self- Rated Health

This study demonstrates that a conversational voice AI system can effectively detect significant functional decline in older adults who self-report high health status, thereby identifying a "hidden risk" population that traditional self-rated health screening often overlooks.

Martha L. Buckley, Meenesh Bhimani, Avik Ray, Herprit Mahal, Michelle Voisard, Jonathan D. Agnew2026-07-17
📄 medicine

Comparison of arthroscopic autologous cancellous bone grafting combined with PRP injection versus autologous osteochondral transplantation for large medial cystic osteochondral lesions of the talus

This retrospective comparative study found that arthroscopic autologous cancellous bone grafting combined with PRP injection and autologous osteochondral transplantation yield similar one-year clinical and radiological outcomes for large medial cystic osteochondral lesions of the talus, though the former offers superior functional recovery at three months postoperatively.

Hao Han, Qi Lu, Long Yang, Fan Hu, Xiangjun Qin, Yuehua Hui, Jie Li, Guangchao Cao, Qinwei Guo, Ji Zhou2026-07-17
📄 medicine

Outcomes of Co-Designed, Place-Based Nutrition Interventions on the Nutritional Status of Women and Young Children in Rural North-Eastern Ghana: A Cluster-Randomized Controlled Trial

A cluster-randomized controlled trial in rural North-Eastern Ghana demonstrated that a co-designed, place-based nutrition intervention significantly reduced child wasting and underweight prevalence while markedly improving haemoglobin levels and reducing anaemia in both mothers and children.

VINCENT ADOCTA AWUUH, Prof. Charles Apprey, Professor Reginald Adjetey Annan2026-07-17
📄 medicine

BH3 mimetics as single agents and with endoxifen in ERα+ breast cancer models

While BH3 mimetics demonstrate anti-proliferative activity in endocrine-sensitive and resistant ERα+ breast cancer models both as single agents and in combination with (Z)-endoxifen in vitro, these combinatorial benefits failed to translate into additional antitumor efficacy in vivo under the specific dosing and scheduling conditions tested.

Lena Batoon, Xiyin Wang, Esther P.B. Rodman, Grace McFarlane, Anna Detry, Carrie Jo Heppelmann, Sandra S. Hammer, Steven (…)2026-07-17
📄 medicine

In vitro activation of µ opioid receptor and cardiac voltage-gated potassium channels hERG and KV7.1/KCNE1 of orphine analogs and their detections in forensic casework

This study reports the forensic detection of emerging orphine analogs in Sweden and demonstrates through in vitro and in silico analyses that these compounds are potent µ-opioid receptor agonists and hERG channel inhibitors, indicating a significant dual risk of respiratory depression and fatal cardiac arrhythmias.

Caitlyn Norman, Nina E Ottosson, Jenny Rosengren Holmberg, Maria Norlund, Evert J Homan, Maria Wikström, Robert Kronstra (…)2026-07-17
📄 medicine

Validation of an AI-computed aided detection system for clinically significant prostate cancer in routine MRI

In a real-world cohort of men with PI-RADS ≥3 lesions, a commercially available AI-CAD system demonstrated high sensitivity for detecting clinically significant prostate cancer, particularly in the peripheral zone, suggesting its potential to support oncologic safety while significantly reducing unnecessary biopsies.

Joan C. Vilanova, Rubén Martínez-Granados, David Bazaga, Encarna Sánchez Bernabé, Almudena Fuster-Matanzo, Claudia Llina (…)2026-07-17
📄 medicine

High Admission Systemic Inflammation Response Index as an Independent Predictor of In-Hospital Adverse Events Among Patients with Acute Heart Failure: A Prospective Cohort Study

This prospective cohort study of 102 patients with acute heart failure demonstrates that a high admission systemic inflammation response index (SIRI) is a strong, independent predictor of in-hospital adverse events, showing excellent discriminatory power with an optimal cut-off of 4.295.

Henry Setiono Sauala, Hendy Wirawan, A.A.Ayu Dwi Adelia Yasmin, Bagus Ari Pradnyana Dwi Sutanegara, I Kadek Susila Surya (…)2026-07-17