medicine papers | Gist.Science

Comparative pharmacodynamic effects of processed Ligustri Lucidi Fructus against postmenopausal osteoporosis and potential mechanisms associated with the wine-steamed preparation: Integrating multidimensional pharmacodynamics, serum chemistry, and spatial metabolomics

This study demonstrates that wine-steamed Ligustri Lucidi Fructus (JLLF) exhibits superior therapeutic efficacy against postmenopausal osteoporosis compared to other processed forms by integrating multidimensional pharmacodynamics, serum pharmacochemistry, and spatial metabolomics to identify its key bioactive constituents and mechanisms involving the modulation of renal tryptophan metabolism and secondary bile acid biosynthesis.

Bocheng Zhou, Siyi Lu, Ruoyi Wang, Tangliang Qian, Tianlun Kang, Xiaoping Liu, Xiujuan Hou2026-10-22

📄 medicine

The Mediating Effect of Social Support in the Relationship between Fear of Progression and Perceived Stress among Lymphoma Patients

This cross-sectional study of 260 young-and-middle-aged Chinese lymphoma patients reveals that social support significantly mediates the relationship between fear of progression and perceived stress, explaining 57.49% of the total effect and highlighting the need for targeted psychosocial interventions.

Yuxin Xing, Lu Li, Liling Mao, Xinyi Su, Tao Xiao2026-10-22

📄 medicine

Psychosocial work-environment profiles and depression, anxiety, and stress among hospital nurses: a latent profile analysis

This study utilized latent profile analysis on 220 Iranian hospital nurses to identify three distinct psychosocial work-environment configurations, revealing that while stress levels varied significantly across these profiles, these differences were sensitive to adjustments for age, work experience, and night-shift status.

Marzieh Belji Kangarlou, Javad Adabi Firozjaee, Monireh Maanavi, Alireza Dehdashti2026-10-21

📄 medicine

Shikonin promoted cell death in renal cancer cells through downregulation of HIF-1 α/AXL pathway

This study demonstrates that shikonin induces apoptosis in renal cancer cells by downregulating the HIF-1α/AXL pathway, suggesting that combining shikonin with AXL-targeted therapy could be an effective treatment strategy for renal cancer.

Jia-Wei Hsu, Li-sung Hsu, Wei-Jen Chen, Yi-Hsuan Chung, Chih-Jung Chen2026-10-21

📄 medicine

Characterization of pharmacological inhibition of the hERG potassium channel by nitazene opioids

This study demonstrates that nitazene opioids directly inhibit the hERG potassium channel through a voltage- and time-dependent gating mechanism involving specific aromatic residues, thereby posing a significant risk of cardiac arrhythmia.

Monisha R Chowdhury, Matteo Baque, Thomas Osborne, Hongwei Cheng, Oliver Hannington, Yihong Zhang, Aziza El Harchi, Caro (…)2026-10-21

📄 medicine

Feasibility and preliminary efficacy of an intervention combining hypnosis and virtual nature exposure in patients following hematopoietic cell transplantation

This randomized feasibility trial demonstrates that a combined hypnosis and virtual nature exposure intervention is safe and well-received by hematopoietic cell transplantation patients, yielding significant immediate reductions in anxiety and fatigue, though no long-term group differences in quality of life were observed at one and three months.

Audrey Laurin, Valentyn Fournier, Orly Desjardins, Jean Roy, Jean-Samuel Boudreault, Maïa Labelle, Pierre Rainville, Mat (…)2026-10-21

📄 medicine

From detection to decision: radiographic predictors of clinical complications in 514 supernumerary teeth: A retrospective cross-sectional study

This retrospective study of 514 supernumerary teeth in 386 children identifies specific radiographic characteristics, including morphology, eruption status, and root development, as significant predictors of clinical complications to guide individualized treatment planning.

Elif Kabacioglu, Betul Sen Yavuz, Selma Yaltkaya, Sebnem Ercalik Yalcinkaya, Ali Mentes2026-10-21

📄 medicine

Distribution of SERPINA1 variants in chronic obstructive pulmonary disease, bronchiectasis, and the combined phenotype: a single-center cross-sectional study

This single-center cross-sectional study of 500 Turkish patients reveals that AATD-associated SERPINA1 variants are significantly more prevalent in the combined COPD-bronchiectasis phenotype (7.5%) than in COPD alone (2.1%) or bronchiectasis alone (0%), highlighting the clinical importance of this specific phenotype and the necessity for broader genotypic screening beyond classical variants.

Derya Aydin, Gokhan Aydin2026-10-21

📄 medicine

EYE CHOOSE: An economic evaluation of surgical strategies for retinal detachment

This study combines a systematic review, network meta-analysis, and economic modeling to conclude that while evidence remains limited, pneumatic retinopexy (PnR) appears to be the most cost-effective surgical strategy for managing rhegmatogenous retinal detachment, offering better vision at a lower cost compared to pars plana vitrectomy and scleral buckle.

Ashleigh Kernohan, Matthew Breckons, Luke Vale, Stephen Rice, Sheila Wallace, Roxane Hillier2026-10-21

📄 medicine

Have We Heard the Consumer’s Plea? Developing a Diet Chart Using Locally Available Food Items for Type 2 Diabetes Mellitus Patients in Ramanagara District, Karnataka: Nominal Group Technique Approach

This study utilized the Nominal Group Technique to develop culturally aligned and regionally appropriate diet charts for Type 2 Diabetes patients in Ramanagara, Karnataka, which demonstrated significantly higher acceptability compared to standard dietary guidelines.

Anvitha Prasad, Angelina Sanjana Selvaraj, Arfa Taj, Shwetha AC, Anand D Meundi2026-10-21

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