📄 Category

medicine

13396 papers

📄 medicine

Dietary practices, obesity and CD4 count among adults with HIV on antiretroviral therapy in Johannesburg, South Africa: a secondary cross- sectional analysis of the ADVANCE trial

In a secondary cross-sectional analysis of the ADVANCE trial, researchers found that while obesity was prevalent among adults with HIV on antiretroviral therapy in Johannesburg, assessed dietary practices were not independently associated with obesity or lower CD4 counts after adjusting for multiple comparisons.

Siphamandla Bonga Gumede, Depika Dwarka, Godspower Akpomiemie, Simiso Sokhela, Tarryn Collings, Jen Manne-Goehler, WD Fr (…)2026-10-21
📄 medicine

Knowledge-graph anchoring enables safer large language model reasoning for rare-tumor management

This study demonstrates that integrating a soft tissue sarcoma knowledge graph into a retrieval-augmented generation pipeline significantly enhances the accuracy, safety, and faithfulness of large language model reasoning for rare-tumor management compared to zero-shot or guideline-only approaches.

Yuan Chu, Chengyi Hua, Qing He, Franka Menge, Christoph Reißfelder, Bernd Kasper, Yimiao Xu, Jens Jakob, Chengpeng Li, C (…)2026-10-21
📄 medicine

Inhibitory potential of 1,10-phenanthroline against Acinetobacter baumannii

This study demonstrates that 1,10-phenanthroline exhibits potent antimicrobial and antibiofilm activity against multidrug-resistant *Acinetobacter baumannii* clinical isolates with low cytotoxicity and favorable pharmacokinetic properties, suggesting its potential as a promising therapeutic agent.

Carolina Oliveira Nazareth, Suelen Lopes Lussanrriaga, Marcelle Oliveira Garcia, Débora Carvalho Rodrigues, Rosemarlei Q (…)2026-10-21
🧬 biology

High seroprevalence of Brucella spp. antibodies in small-ruminant milk and poor brucellosis-related awareness among herders in Maiduguri, northeastern Nigeria

This study reveals a high seroprevalence of *Brucella* antibodies in small-ruminant milk in Maiduguri, Nigeria, alongside poor herder knowledge and practices regarding brucellosis, highlighting a significant One Health risk driven by raw milk consumption and unsafe animal handling.

Bukar Tijjani, Saleh Mohammed Jajere, Abdulyekeen Olawale Tijjani, Muhammad Abubakar Sadiq, Wendy Anne Beauvais2026-10-21
📄 medicine

Get Britain Working: qualitative evaluation of a policy for work and health at early implementation sites

This qualitative evaluation of the "Health and Growth Accelerators" pilot in England finds that while collaboration with existing programs is vital, the initiative's success in addressing economic inactivity linked to ill health is significantly constrained by high ambiguity, inter-organizational conflict, and the pressures of short funding cycles and rapid scaling.

Mhorag Goff, Karen Spilsbury, Rachel Meacock, Kasonde Mwaba, Peter Bower2026-10-21
📄 medicine

Comparative Burden and Attributable Risk of Hepatocellular Carcinoma in China versus G20 Nations from 1990 to 2040: A Joinpoint Regression and Bayesian Age-Period-Cohort Modeling Study

This study utilizes advanced statistical modeling to analyze hepatocellular carcinoma trends in China and G20 nations from 1990 to 2040, revealing a decline in age-standardized rates driven by demographic shifts and a critical etiological transition from viral hepatitis to metabolic risk factors, thereby underscoring the urgent need for targeted prevention strategies to address persistent inequalities and emerging metabolic burdens.

Zhihe Luo, Zhenhua Hao, Min Tang, Shuang Liang, Riyu Du, Zheshuang Li, Qianning Ma, Yanhui Shen, Yuzhen Qi, Liang Wang (…)2026-10-21
📄 medicine

An acoustic coupling fluid improves intraoperative ultrasound image quality during glioma surgery: Results of a Pivotal Multicenter Study (NCT04734444)

This pivotal multicenter study demonstrates that the use of the tissue-mimicking acoustic coupling fluid SonoClear significantly reduces ultrasound artifacts and improves image quality during glioma resection, thereby enhancing intraoperative guidance without causing serious device-related adverse events.

Francesco DiMeco, Massimiliano Del Bene, Giovanni Carone, Annica Piccardi, Jan Coburger, Andrej Steno, Rainer Ritz, Benj (…)2026-10-21
📄 medicine

Sex-specific alterations in muscle health and related protein and amino acid kinetics in different stages of frailty

This study reveals that frailty progression in older adults involves distinct sex-specific metabolic and functional changes, characterized by early functional decline in both sexes but divergent patterns of muscle loss, bone density reduction, and protein breakdown kinetics that underscore the need for personalized nutritional and therapeutic interventions.

Minchae C. Kang, Nicolaas E.P. Deutz, Laura E. Ruebush, Mariëlle P.K.J. Engelen2026-10-21