📄 medicine

Financial Toxicity and Life Satisfaction in Working-Age Cancer Survivors: A National Study of Pathways and Buffers

This national study of working-age US cancer survivors reveals that financial toxicity significantly reduces life satisfaction primarily by increasing depressive symptoms and restricting community participation, with these harmful effects concentrated at low financial well-being levels but effectively buffered by psychological resources like coping flexibility and trait hope rather than social support.

Ada Chen, Jing Tao, Lidian Chen2026-10-21
📄 medicine

Multi-Planar Reconstruction and 3D Volume Rendering as Tools of Anatomical Dissection and Morphometry on the Example of Cadaveric Study of Inferior Medial Genicular Artery

This study validates that 3D volume rendering and multiplanar reconstruction are reliable, reproducible, and non-invasive alternatives to traditional cadaveric dissection for analyzing the inferior medial genicular artery, demonstrating strong inter-observer agreement and measurement consistency across different software platforms for vessels larger than 0.95 mm.

Julia Szopa, Laura Fortuna, Paweł Gębski, Filip Lipiński, Bogdan Ciszek, Beata Ciszkowska-Łysoń, Robert Śmigielski2026-10-21
📄 medicine

Comparisons of retention, microleakage, penetration and caries inhibition of fissure sealant and resin infiltration in pit and fissure caries: an in vitro study

This in vitro study demonstrates that both fissure sealants and resin infiltration (with 60s or 120s etching) offer comparable effectiveness in preventing microleakage and inhibiting caries progression in non-cavitated occlusal lesions, supporting their use as equivalent minimally invasive treatment options.

Yi Tan, Meijiao Yu, Zijun Chen, Cynthia Kar Yung Yiu, Phoebe Pui Ying Lam2026-10-21
📄 medicine

A Systematic Review and Descriptive Quantitative Synthesis of Artificial Intelligence in Cervical Cancer Screening and Diagnosis

This systematic review of 898 studies on artificial intelligence in cervical cancer screening and diagnosis reveals broad application across multiple modalities but highlights significant methodological heterogeneity and reporting limitations that preclude pooled quantitative analysis, underscoring the urgent need for standardized reporting, external validation, and prospective clinical evaluation.

H Aswini, T Benil2026-10-21
📄 medicine

Synoptic procedural reporting to improve quality indicators in systematic Staging Endobronchial Ultrasound (EBUS) in Non-small cell lung cancer (NSCLC): protocol for an ambispective multi-centre quality improvement study

This protocol outlines an ambispective, international, multicentre quality improvement study designed to evaluate whether implementing synoptic procedural reporting enhances the completeness, accuracy, and feasibility of systematic staging endobronchial ultrasound (EBUS) for non-small cell lung cancer (NSCLC) compared to traditional narrative reporting.

Ashleigh Witt, Nicole M Rankin, Sandy Errey-Clarke, Matthew Evison, David Manners, Fayez Kheir, Dexter Wiseman, Neal Nav (…)2026-10-21
📄 medicine

Vitality maintenance among older adults in residential care facilities: a qualitative study of the dual perspectives of older adults and multidisciplinary staff

This qualitative study in Shanghai explores the dual perspectives of older adults and staff on maintaining vitality in residential care, revealing that effective support requires stratified, person-centered strategies that prioritize autonomy, social connection, and adequate staffing to overcome barriers like physical decline and institutional constraints.

Yanli Wang, Junqiao Wang, Yuru Shu, Ying Sun, Yanhong Gu2026-10-21
📄 medicine

A Novel Homozygous Canonical Splice-Donor VWF Variant Causing Type 3 von Willebrand Disease in an Iranian Patient: Case Report

This case report describes a 16-year-old Iranian female with Type 3 von Willebrand disease caused by a novel homozygous canonical splice-donor variant in the VWF gene, confirming the diagnosis through whole-exome sequencing and highlighting the importance of molecular analysis for genetic counseling in severe inherited bleeding disorders.

Narjes Bakhtari, Morvarid Ataebi, Azam Bolhassani, Shadi Tabibian2026-10-21
📄 medicine

Successful emicizumab prophylaxis in treatment-refractory acquired von Willebrand syndrome associated with rheumatoid arthritis

This case report describes the first successful use of emicizumab prophylaxis to achieve sustained clinical hemostasis in a patient with treatment-refractory acquired von Willebrand syndrome associated with rheumatoid arthritis, offering a promising alternative when conventional therapies fail.

Evan Botterman¹, Ravi Upadhyay², Zachary Israeli¹, Yash Shah¹, Alice Cohen²2026-10-21