4907 papers
ProToxNet is a novel framework that integrates proteome-wide drug–protein binding predictions with tissue-specific gene expression to accurately predict tissue-stratified adverse events for both known and novel drugs, demonstrating strong generalization and clinical validity across multiple benchmarks.
This retrospective cohort study of 865 hip replacement patients found that perioperative administration of acetate-buffered balanced crystalloid solution (SPMCG) was significantly associated with a reduced risk of postoperative myocardial injury within 3 and 7 days compared to non-SPMCG use.
This study analyzes the 2022 Liberia Malaria Indicator Survey data to reveal significant spatial heterogeneity in under-five malaria prevalence, identifying southern and southeastern hotspots driven by rainfall, vegetation, and water proximity, thereby advocating for geographically differentiated control strategies.
This study analyzed data from the China Health and Retirement Longitudinal Study (CHARLS) and the US Health and Retirement Study (HRS) to find that while rapid kidney function decline showed a trend toward increased hip fracture risk in older adults, the association was not statistically significant in either cohort.
This prospective observational study found that a ChatGPT-4o-based triage model demonstrated significantly higher concordance with emergency physician categorization than emergency medical technicians when using identical structured clinical data, though this agreement reflects rater consistency rather than diagnostic validity and is accompanied by a tendency to over-triage high-acuity patients.
This study identifies a specific ubiquitination binding site between NEDD4L and ACE2 and demonstrates that blocking this interaction via point mutation alleviates hypoxia-induced pulmonary arterial hypertension, revealing a novel therapeutic target for the disease.
This study identifies that C5a/C5aR1 signaling specifically activates sensory neuron-associated macrophages in the dorsal root ganglia to drive neuropathic pain via IL-1β, while excluding the involvement of C5aR1 in spinal microglia, peripheral injury-site macrophages, or primary nociceptive neurons.
In a propensity-weighted retrospective cohort study of septic shock patients with tachycardia, phenylephrine failed to improve heart rate control compared to norepinephrine and was associated with increased risks of new renal replacement therapy and fewer ventilator-free days, arguing against its routine use even in this specific population.
This study elucidates that hemodynamic disruption in nephrotic syndrome triggers glomerular barrier injury via endothelial glycocalyx degradation, a mechanism validated through integrated in vivo and organ-on-a-chip models and shown to be effectively mitigated by sulodexide therapy.
This study demonstrates that a KMS-SECI-based educational module combined with video-assisted learning and husband support significantly improves knowledge, self-efficacy, and the rate of early breastfeeding initiation within one hour among primigravida mothers compared to conventional care.