4951 papers
This three-arm randomized pre-post study found that while a clean ketogenic diet alone produced the greatest weight loss and cardiometabolic improvements, combining it with intermittent fasting provided additional, independent benefits for glycemic control and grip strength.
Dexmedetomidine attenuates methamphetamine-induced hyperthermia and hyperlocomotion in rats primarily through α2A-adrenergic receptor mechanisms by suppressing the release of dopamine and noradrenaline in the anterior hypothalamus, suggesting its potential as a therapeutic intervention for severe methamphetamine intoxication.
This multicentre observational pilot study demonstrates that the co-designed PalliDoc Mobile App is a sustainable and beneficial addition to paediatric palliative home care in Germany, showing high adoption rates, good usability, and effective asynchronous communication, though synchronous video consultations had no measurable impact on care delivery.
The paper introduces ECG-LLM, a large language model trained on over 679,000 ECG studies that leverages multimodal supervision to enable question-driven cardiovascular reasoning, allowing front-line clinicians to derive complex cardiac phenotypes and diagnostic insights directly from 12-lead ECGs without immediate access to advanced imaging.
This study demonstrates that an explainable machine learning model utilizing organ-specific dosiomics features from CyberKnife SBRT plans can effectively predict late genitourinary toxicity in prostate cancer patients, achieving high accuracy while identifying clinically interpretable risk drivers through SHAP analysis.
This study demonstrates that structure-guided small molecules can selectively target a unique RNA conformation induced by the CFTR W1282X mutation to stabilize the transcript, thereby partially restoring CFTR function in cystic fibrosis cells.
In a propensity-matched study of an Asian population, kinematic alignment in primary total knee arthroplasty demonstrated comparable or superior two-year functional outcomes and patient satisfaction relative to mechanical alignment, with equivalent safety and revision-free survival rates.
This prospective observational study found that while microplastics are universally present in the bronchoalveolar lavage fluid of both newly diagnosed lung cancer patients and controls, their densities are comparable between the two groups, suggesting that these particles reflect general environmental inhalation rather than serving as a specific indicator of malignancy.
This study combines a single-center cohort analysis and a meta-analysis to reveal that the risk of stroke-associated pneumonia following intracerebral hemorrhage is significantly higher than previously reported, with evidence suggesting a concerning upward trend in incidence since 2019.
In a large nationwide Korean cohort study, initiating SGLT2 inhibitors as second-line therapy for type 2 diabetes was associated with a significantly lower 180-day risk of acute kidney injury compared to sulfonylureas, a protective effect that persisted in patients with heart failure but was attenuated among those with pre-existing chronic kidney disease.