📄 Category

medicine

5451 papers

📄 medicine

Value-Based Healthcare Model of Medical and Pharmaceutical Care for Patients With Coronary Artery Disease with Comorbid Conditions: Cost- Benefit Analysis in the Healthcare Setting of Ukraine

This study proposes and validates a value-based, three-level pharmaceutical care model for Ukrainian patients with coronary artery disease and comorbidities, demonstrating through cost-benefit analysis that integrating clinical pharmacists and original fixed-dose combinations significantly reduces cardiovascular events and generates substantial net economic benefits across multiple healthcare perspectives.

Natalia Bilousova, Tamara Mahanova, Natalia Tkachenko, Vasyl Mykhalchuk, Nataliia Kozhuharyova, Maryna Dolzhenko2026-07-07
📄 medicine

Development and External Validation of a Machine Learning Model for Postoperative Infection After Cardiopulmonary Bypass Surgery

This study developed and externally validated an interpretable Gradient Boosting Machine (GBM) model using eight early postoperative variables to effectively predict 30-day infection risks in patients undergoing cardiopulmonary bypass surgery.

Yiwei Lin, Jingyu Li, Kaiqiang Fan, Tianying Qiu, Zhichao Li, Shujie Wang, Chuan Guo, Lei Zhang, Yang Zhao, Youzhuang Zh (…)2026-07-07
📄 medicine

Detecting tumor-associated peptides from the plasma-derived soluble immunopeptidome in human hepatocellular carcinoma patients: a pilot study

This pilot study demonstrates that plasma-derived soluble HLA-I peptides in hepatocellular carcinoma patients contain tumor-associated antigens shared with tumor tissue, suggesting that sHLA-I profiling is a promising minimally invasive strategy for identifying actionable targets and tumor-specific signatures in HCC.

Amy L. Kessler, Yannick S. Rakké, Lisa Bokhout, Robbie J. Luijten, Wouter A.S. Doff, Karel Bezstarosti, Roel F.A. Pieter (…)2026-07-07
📄 medicine

Temporal Inverted Internal Limiting Membrane Flap Technique versus Conventional Internal Limiting Membrane Peeling Technique for Large Macular Holes: A Retrospective Comparative Study

This retrospective comparative study demonstrates that the temporal inverted internal limiting membrane flap technique yields superior visual acuity, outer retinal layer recovery, and closure rates—particularly for macular holes ≥550 µm—compared to conventional internal limiting membrane peeling for large full-thickness macular holes.

Sule Acar Duyan, Gülay Güler Canözer, Şaban Gönül2026-07-07
📄 medicine

30-Day Morbidity and Mortality of Surgical Management for Lower Limb Vascular Injury in Yemeni Civilians: A Prospective Cohort Study

This prospective cohort study of 78 Yemeni civilians with lower limb vascular injuries reveals a 9% 30-day mortality and 51.3% morbidity rate, identifying hemodynamic instability as the primary predictor of death and concomitant nerve injury as the decisive factor for functional recovery, while highlighting the critical need for improved pre-hospital triage and surgical evacuation.

Aref Ali Al-Hashedi, Mohammed Ali Eissa, Nabeel Yahiya Al-Madwahi, Haitham Mohammed Jowah2026-07-07
📄 medicine

Longitudinal Associations Between BMI, Physical Activity, and Sleep Quality in Chinese School-Aged Children: A Two-Wave Study

This two-wave longitudinal study of Chinese school-aged children reveals a self-reinforcing cycle where higher BMI predicts increased low-intensity physical activity, which in turn leads to poorer sleep quality and subsequently reduced moderate-to-vigorous physical activity, thereby exacerbating obesity.

Xiaoya Yin, Lijing Sun, Qiong Yan, Zhe Zhang, Yani Zhai, Xinyi Zhou, Xuelai Wang, Shuman Li, Zhengzhong Wang, Chunyan Lu (…)2026-07-07
📄 medicine

Psychological Disturbances at ICU Discharge: Evaluation Using the Intensive Care Psychological Assessment Tool (IPAT) and Association with Clinical Features: An observational cross-sectional study

This observational cross-sectional study of 392 ICU patients demonstrates that the Intensive Care Psychological Assessment Tool (IPAT) effectively identifies acute psychological disorders at discharge, revealing that advanced age, higher APACHE-II scores, prior psychiatric history, use of psychotropic medications, and non-invasive mechanical ventilation are significant risk factors, while also validating a specific IPAT cut-off score for predicting delirium.

Melek Doganci, Guler Eraslan Doganay, Derya Hosgun, Emine Banu Cakiroglu, Maside Ari, Murat Yildiz, Mustafa Ozgur Cirik (…)2026-07-07
📄 medicine

Integrated Atrial Fibrillation Management Using Combined Pulsed-Field Ablation and Left Atrial Appendage Occlusion: Early Real-World Outcomes

This real-world study demonstrates that combining pulsed-field ablation for atrial fibrillation with left atrial appendage occlusion in a single session is feasible and safe, yielding low rates of peri-device leaks and complications while significantly reducing overall healthcare utilization compared to performing the procedures separately.

Veniamin Melnychuk, Osama Srour, Elias Wakim, Julian Sifre Seda, Gunjan Mundhra, Firas El Sabbagh2026-07-07
📄 medicine

Association Between Maternal Glycemic Status and Urinary Infection Markers During Pregnancy: A Prospective Observational Study

This prospective observational study of 2,017 pregnant women reveals that while gestational diabetes mellitus is associated with higher rates of urinary infection markers, even within the non-diabetic population, elevated fasting plasma glucose levels independently predict increased risks of positive urine cultures, Group B Streptococcus colonization, and asymptomatic bacteriuria, suggesting that glycemic risk should be viewed as a continuous spectrum rather than a categorical threshold.

Gamze KARABABA, Kazım UCKAN, Yusuf BASKIRAN2026-07-07
📄 medicine

Prognostic Impact of CA 19-9 at Diagnosis in Metastatic Early-Onset Colorectal Cancer (<50 Years): A Retrospective Cohort Study from Uruguay, 2008–2023

In a nationwide retrospective cohort of 675 Uruguayan patients under 50 with metastatic colorectal cancer, elevated CA 19-9 levels at diagnosis were independently associated with significantly shorter overall survival, establishing its potential as a low-cost prognostic tool for risk stratification in resource-constrained settings.

Maria Belen Insagaray, Diego Ferreira, Guadalupe Herrera, Noelia Strazzarino, Gabriel Krygier, Mauricio Cuello, Lucia De (…)2026-07-07