medicine papers | Gist.Science

Impact of body mass index on the clinical outcomes of immune checkpoint inhibitor combination therapy for advanced renal cell carcinoma: insights from gene expression and tumor-infiltrating immune cell profile

This study demonstrates that while body mass index (BMI) does not significantly influence outcomes for advanced clear-cell renal cell carcinoma patients treated with dual immune checkpoint inhibitor therapy, underweight patients experience significantly poorer survival when receiving ICI-VEGFR tyrosine kinase inhibitor combinations, a disparity potentially driven by the downregulation of angiogenesis-related pathways in underweight individuals.

Hiroki Ishihara, Hironori Fukuda, Akihiro Kumono, Yuki Nemoto, Takayuki Nakayama, Koichi Nishimura, Shinsuke Mizoguchi (…)2026-07-07

📄 medicine

Association Between Postoperative Delirium and Salivary Cortisol Levels in Children: A Pilot Study

This pilot study demonstrates that elevated postoperative salivary cortisol levels serve as a valid objective biomarker for pediatric delirium, significantly enhancing diagnostic accuracy when combined with PAED scale assessments.

chengbo Huang, youwen Xu, lan Luo, fangyi Wang, Shihui Bao, yi Wang2026-07-07

📄 medicine

Association of Dual Sensory Impairment-Depression Comorbidity Patterns with Fall Risk Among Middle-Aged and Older Adults: A Nationwide Cohort Study

This nationwide cohort study of nearly 10,000 Chinese adults reveals that the comorbidity of dual sensory impairment and depression significantly increases fall risk more than either condition alone, with the two factors mutually mediating each other's impact on falls.

Shuyang Dai, Yingli Qiao, Gaoli Zhang, Yuhui Deng, Poshi Xu2026-07-07

📄 medicine

Assessment of Antibiotic Use in Pediatric Departments in Boma, Democratic Republic of the Congo, according to the WHO AWaRe Classification

A retrospective study of 420 pediatric cases in Boma, DRC, reveals that antibiotic prescribing is dominated by WHO "Watch" category drugs and driven by clinical experience rather than diagnostic testing, deviating significantly from international AWaRe guidelines despite high recovery rates.

Tarcisse Kilara, Thérèse Mpiempie, Jean Paul Pholo, Teins Kasongo, Mireille Ngale, Jean Paul Divengi, Mamie Kondani, Fél (…)2026-07-07

📄 medicine

Nutritional Status, Personal Hygiene Practices, and Health-Seeking Behaviour Among Children in Child Care Institutions: A Mixed-Methods Cross-Sectional Study from Bhubaneswar, Odisha, India

This mixed-methods study of children in Bhubaneswar, India, reveals a high prevalence of stunting and thinness in Child Care Institutions, identifies older age and male gender as protective factors against thinness, and highlights the critical need for sustained government funding to improve nutrition, hygiene, and health-seeking behaviors.

Subhashreemalini Sahoo, Pradeep Kumar Panda, Paramjot Panda, Bharati Swaraj Sahu2026-07-07

📄 medicine

The Bridlington Eye Assessment Project Age-related Macular Degeneration Study (BEAP-AMD2): Characterising Phenotype-Genotype Associations in a UK Population Cohort

This prospective cross-sectional study of a UK population aged 55 and older characterizes the prevalence of age-related macular degeneration (AMD) and its association with specific genetic variants on chromosomes 1 and 10, revealing that while retinal and choroidal thickness progressively decline with AMD severity, these structural changes show only a trend toward correlation with genetic risk, which otherwise aligns with findings in other Caucasian cohorts.

Winfried Amoaku, Christian Pappas, Richard Gale, Vittorio Silvestri, Laura Cushley, Jill Hageman, Reuben Amoaku, Rukhsar (…)2026-07-07

📄 medicine

Associations of Voluntary and Required Group Physical Activity with Depressive Symptoms Among Chinese Adolescents: A Cross-sectional and Longitudinal Approach

This study reveals that while voluntary physical activity is robustly linked to fewer depressive symptoms in Chinese adolescents, required group physical activity shows no cross-sectional benefit and is longitudinally associated with increased depressive symptoms, particularly among girls.

Yuru Du, Jianqiang Wang, Zheng Liu, Siyuan Chen, Youdong Li2026-07-07

📄 medicine

Cardiorenal Stress Phenotype, Renal Recovery, and Survival Outcomes in Newly Diagnosed Multiple Myeloma with Renal Impairment: A Real-World Cohort Study

This real-world cohort study demonstrates that newly diagnosed multiple myeloma patients with renal impairment exhibit a distinct cardiorenal stress phenotype characterized by elevated NT-proBNP and LDH, which independently predicts heterogeneous renal recovery and worse overall survival, suggesting that hematologic response alone is insufficient for prognosis and that cardiorenal stress stratification should be integrated into management.

Xiaoyan Liu, Jie Xiao, Xiuju Wang, Danian Nie, Chouxia Zhao, Dana Feng2026-07-07

📄 medicine

Cross-Sectional Analysis of Correlates of Active School Travel in 190,715 Adolescents from 53 Countries

This large-scale cross-sectional study of over 190,000 adolescents from 53 countries identifies sex, peer support, and parental understanding as significant global correlates of active school travel, highlighting the need for interventions that address social influences and gender disparities to promote this health-promoting behavior.

Keyang Wang, Jie Fei2026-07-07

📄 medicine

Short-Term Blue-Blocking Intervention Improves Photostress Recovery Under Blue- Light Exposure

This study demonstrates that while high-intensity blue light exposure prolongs photostress recovery time in healthy young adults, the use of blue-blocking lenses, particularly Dura Vision, significantly ameliorates this effect without indicating macular damage or sleep disruption.

Sristi Nayak, Stelyna Joylin, Nagarajan T2026-07-07

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