📄 Category

medicine

5451 papers

📄 medicine

Nrf2/HO-1 Signaling Axis Activation Underpins the Endogenous "Rest-Relief" Mechanism in a Rat Model of Lumbar Spinal Stenosis-Induced Neurogenic Intermittent Claudication

This study demonstrates that in a rat model of lumbar spinal stenosis, the endogenous relief of neurogenic intermittent claudication during rest is driven by the activation of the Nrf2/HO-1 signaling axis, which mitigates oxidative stress and neuroinflammation caused by cyclic ischemia-reperfusion, suggesting this pathway as a promising target for non-surgical therapeutic interventions.

Daiyuan Liu, Haibao Wen, Minrui Fu, Jinghua Gao, Chunyu Gao, Luguang Li, Jianguo Li, Minshan Feng, Wu Sun2026-07-07
📄 medicine

Impact of imperatorin and isoimperatorin on the pharmacokinetics of abemaciclib both in vivo and in vitro

This study demonstrates that co-administration of imperatorin or isoimperatorin significantly alters the pharmacokinetics of the breast cancer drug abemaciclib in rats by inhibiting its metabolism, likely through competition for CYP3A4 binding, suggesting a need for clinical caution when combining these agents.

Chengfeng Wang, Jianfeng Wang, Zebei Lu, Yu Wang, Abdullah Al Mamun, Md Siddiqul Islam, Shuanghu Wang, Yunfang Zhou, Min (…)2026-07-07
📄 medicine

Impact of non-invasive ventilation on lung hyperinflation: A physiological study using electrical impedance tomography in COPD patients

This prospective physiological study of 30 stable COPD patients demonstrates that non-invasive ventilation can induce a reduction in lung volume, which is associated with improved sleep quality and a more pronounced reduction in dyspnea.

Alexandre Garcia, Carole Decloedt, Pierre Schilfarth, Marina Guecamburu, Arthur Pavot, Arnaud Maurac, Benjamin Repusseau (…)2026-07-07
📄 medicine

Beyond the pandemic declaration: Persistent daily health complaints in diabetic COVID-19 survivors and the protective effect of prior vaccination in Indonesian primary care

This cross-sectional study of 420 diabetic COVID-19 survivors in Indonesian primary care reveals that pre-infection vaccination is associated with a 45% reduction in persistent daily health complaints, highlighting the importance of integrating vaccination promotion into chronic disease management in low- and middle-income countries.

Putri Bungsu Machmud, Husnul Khatimah, Renti Mahkota, Jessica Veronica, Arie Wahyu Wijayanto2026-07-07
📄 medicine

Multimodal imaging features of intra-parenchymal schwannoma

This retrospective study of 22 intra-parenchymal schwannoma cases characterizes the condition's distinct multimodal imaging profile, which includes well-circumscribed solid-cystic masses with significant edema, heterogeneous contrast enhancement, high perfusion, unrestricted diffusion, and specific MRS metabolic patterns, to aid in their accurate diagnosis.

Jiaying Gong, Zelan Ma, Yan Deng, Qianwen Guan, Zhongwen Zhou, Shukun Liao, Ke Sun, Na Shen, Donghui Gan, Hanqiu Liu2026-07-07
📄 medicine

Surrogate Decision-Making Confidence Across Acute and General Scenarios: Predictors and Ethical Reasoning in a Mixed-Methods Study

This mixed-methods study reveals that surrogate decision-makers report significantly lower confidence in acute scenarios compared to general ones, with self-efficacy emerging as the strongest predictor of confidence across both contexts, suggesting that targeted preparation to boost self-efficacy could improve decision-making readiness.

Yuxin Zhao, Onyinye Mbanefo, Sean Lawrence, Nethra Rajeshkumar, Emily Jon, Benjamin Katz, Pamela Teaster2026-07-07
📄 medicine

Post-operative Pain of Endoscopic versus Mini-open Carpal Tunnel Release: A Randomized Controlled Trial

This Level I randomized controlled trial demonstrates that while both endoscopic and mini-open carpal tunnel release are equally safe and effective for long-term outcomes, the endoscopic approach offers superior early pain reduction and faster return to work without increasing complication risks.

Patarpon Inthawong, Woraphon Jaroenporn, Korntanat Thongvinij, Thanapol Wangrattanapranee, Lertkong Nitiwarangkul, Wisar (…)2026-07-07
📄 medicine

A Real-World Study of IABP Monitoring in Critically Ill Patients with Severe Fever with Thrombocytopenia Syndrome

This retrospective cohort study of 374 critically ill SFTS patients demonstrates that invasive arterial blood pressure monitoring not only provides more accurate hemodynamic assessment during hypotensive shock but also significantly reduces the incidence and severity of upper limb skin ecchymosis compared to non-invasive monitoring.

Xiaodan LI, Hongyan LI, Puhui LIU, Lin LIU, Jiehong ZHU, Yongmei WANG, Weiyu SUI2026-07-07
📄 medicine

Determinants of healthy dietary patterns among Iranian adults with type 2 diabetes: evidence from the Stepwise Approach to Noncommunicable Risk Factor Surveillance (STEPS 2021)

This cross-sectional study of Iranian adults with type 2 diabetes reveals that higher educational attainment, greater wealth, health insurance coverage, and non-smoking behavior are independently associated with adherence to healthy dietary patterns.

Fatemeh Sadat Mirtaher, Neda Cheraghloo, Atefeh Amrollahi bioky, Farima Farsi, Sasan Sharghi, Yosra Azizpour, Asieh Mans (…)2026-07-07
📄 medicine

In-depth interviews and biofeedback in a mixed-methods study: How people with rare diseases experience sexuality

This mixed-methods study reveals that while individuals with rare diseases report generally positive attitudes and comfort regarding sexuality in surveys, in-depth interviews and biofeedback data expose a significant gap between these self-reported metrics and their actual lived experiences, characterized by a lack of professional dialogue and physiological fluctuations, thereby highlighting the urgent need for targeted interventions to integrate sexuality into their overall well-being.

Ariadna García Prat, María Camino Escolar Llamazares, María Yolanda González Alonso, Begoña Ruiz García, Cristina Pérez (…)2026-07-07