5451 papers
This study validates the Quality of Patient-Centered Outcomes Research Instrument (QPCOR) as a reliable, psychometrically sound tool for measuring the quality of patient-centered research partnerships, offering a standardized alternative to qualitative evaluations to enhance cross-study comparability and assess relational engagement.
This cross-sectional pilot study of 200 U.S. healthcare workers found that occupational burnout is significantly associated with elevated anxiety, depression, and PTSD symptoms, with perceived sleep quality acting as a moderator that specifically influences the relationship between burnout and depressive symptoms at low to moderate burnout levels.
This mixed-methods study identifies that while existing digital pain self-management tools lack cultural responsiveness for South Asians, co-developing evidence-based, culturally tailored resources that integrate symptom monitoring, psychological support, and social context is essential to effectively engage people with chronic musculoskeletal pain in Pakistan.
This study characterizes the pharmacokinetic profile of the gastrointestinal acute radiation syndrome mitigator YK-4-250 in male and female mice, revealing that while radiation exposure significantly impairs systemic clearance and alters absorption kinetics in a dose- and sex-dependent manner, a higher 40 mg/kg dose effectively equalizes exposure between sexes, suggesting a need for adaptive dosing strategies in radiation-mitigative therapies.
This integrated SEER-TCGA study reveals that sigmoid colon cancer carries a significantly better prognosis than splenic flexure/descending colon cancer due to distinct molecular and immune microenvironmental features, supporting the need to treat left-sided colon cancer as heterogeneous rather than a homogeneous entity.
This multi-component pilot evaluation in rural Ethiopia demonstrates that task-shifting long-acting reversible contraceptive services to Level IV Health Extension Workers is a clinically safe, effective, and highly acceptable strategy for expanding access, though it highlights the need for targeted training and ongoing supervision to address specific knowledge gaps and improve competency in IUCD and Jadelle procedures.
This experimental study on anesthetized beagles demonstrates that peripheral venous pressure (PVP) correlates linearly with central venous pressure (CVP) across a broad range, and that incorporating tissue pressure into an estimation formula significantly improves CVP prediction accuracy, particularly in low-pressure states.
This study demonstrates that quantitative infrared reflectivity analysis via meibography reveals distinct reflectivity patterns among different meibomian gland-related eyelid lesions, with chronic chalazia showing significantly lower reflectivity than sebaceous gland carcinoma, thereby offering a useful diagnostic marker for differentiating these conditions.
This case report describes a 72-year-old man with anti-PL7 antisynthetase syndrome who developed disseminated histoplasmosis due to the reactivation of a latent infection decades after initial exposure following a switch to infliximab therapy, highlighting the critical need to consider fungal reactivation in immunocompromised patients presenting with new granulomatous lung disease even when initial microbiological tests are negative.
This study demonstrates that applying tactile biofeedback to increase stance time in healthy individuals acutely enhances key propulsive gait mechanics, such as trailing limb angle and peak propulsive force, suggesting a cost-effective rehabilitation strategy for improving paretic limb propulsion in stroke survivors.