5584 papers
This pilot study demonstrates that plasma-derived soluble HLA-I peptides in hepatocellular carcinoma patients contain tumor-associated antigens shared with tumor tissue, suggesting that sHLA-I profiling is a promising minimally invasive strategy for identifying actionable targets and tumor-specific signatures in HCC.
This retrospective comparative study demonstrates that the temporal inverted internal limiting membrane flap technique yields superior visual acuity, outer retinal layer recovery, and closure rates—particularly for macular holes ≥550 µm—compared to conventional internal limiting membrane peeling for large full-thickness macular holes.
This prospective cohort study of 78 Yemeni civilians with lower limb vascular injuries reveals a 9% 30-day mortality and 51.3% morbidity rate, identifying hemodynamic instability as the primary predictor of death and concomitant nerve injury as the decisive factor for functional recovery, while highlighting the critical need for improved pre-hospital triage and surgical evacuation.
This two-wave longitudinal study of Chinese school-aged children reveals a self-reinforcing cycle where higher BMI predicts increased low-intensity physical activity, which in turn leads to poorer sleep quality and subsequently reduced moderate-to-vigorous physical activity, thereby exacerbating obesity.
This observational cross-sectional study of 392 ICU patients demonstrates that the Intensive Care Psychological Assessment Tool (IPAT) effectively identifies acute psychological disorders at discharge, revealing that advanced age, higher APACHE-II scores, prior psychiatric history, use of psychotropic medications, and non-invasive mechanical ventilation are significant risk factors, while also validating a specific IPAT cut-off score for predicting delirium.
This real-world study demonstrates that combining pulsed-field ablation for atrial fibrillation with left atrial appendage occlusion in a single session is feasible and safe, yielding low rates of peri-device leaks and complications while significantly reducing overall healthcare utilization compared to performing the procedures separately.
This prospective observational study of 2,017 pregnant women reveals that while gestational diabetes mellitus is associated with higher rates of urinary infection markers, even within the non-diabetic population, elevated fasting plasma glucose levels independently predict increased risks of positive urine cultures, Group B Streptococcus colonization, and asymptomatic bacteriuria, suggesting that glycemic risk should be viewed as a continuous spectrum rather than a categorical threshold.
In a nationwide retrospective cohort of 675 Uruguayan patients under 50 with metastatic colorectal cancer, elevated CA 19-9 levels at diagnosis were independently associated with significantly shorter overall survival, establishing its potential as a low-cost prognostic tool for risk stratification in resource-constrained settings.
This real-world study utilizing U.S. claims data reveals that pregnant women with generalized myasthenia gravis face significantly higher risks of adverse pregnancy outcomes and disease crises while receiving fewer treatments and incurring higher overall healthcare costs compared to their non-pregnant or non-disease counterparts.
This case report highlights the importance of distinguishing true from "false" transvalvular gradients caused by hyperdynamic states following TAVR by incorporating flow-dependent parameters like stroke volume to guide accurate diagnosis and management.