5613 papers
This cross-sectional study of 170 Indian primary school teachers found that while chronotype showed no association with obesity indicators, higher social jetlag was significantly linked to increased subcutaneous fat and decreased skeletal muscle mass, independent of sleep quality and duration.
This study developed and validated a highly sensitive and specific fluorescence-based endpoint genotyping assay using minor groove binding probes to rapidly and accurately detect the A2063G and A2064G macrolide resistance mutations in *Mycoplasma pneumoniae*, demonstrating perfect agreement with commercial standards in clinical samples.
This study demonstrates that in a rat model of lumbar spinal stenosis, the endogenous relief of neurogenic intermittent claudication during rest is driven by the activation of the Nrf2/HO-1 signaling axis, which mitigates oxidative stress and neuroinflammation caused by cyclic ischemia-reperfusion, suggesting this pathway as a promising target for non-surgical therapeutic interventions.
This study demonstrates that co-administration of imperatorin or isoimperatorin significantly alters the pharmacokinetics of the breast cancer drug abemaciclib in rats by inhibiting its metabolism, likely through competition for CYP3A4 binding, suggesting a need for clinical caution when combining these agents.
This prospective physiological study of 30 stable COPD patients demonstrates that non-invasive ventilation can induce a reduction in lung volume, which is associated with improved sleep quality and a more pronounced reduction in dyspnea.
This cross-sectional study of 420 diabetic COVID-19 survivors in Indonesian primary care reveals that pre-infection vaccination is associated with a 45% reduction in persistent daily health complaints, highlighting the importance of integrating vaccination promotion into chronic disease management in low- and middle-income countries.
This retrospective study of 22 intra-parenchymal schwannoma cases characterizes the condition's distinct multimodal imaging profile, which includes well-circumscribed solid-cystic masses with significant edema, heterogeneous contrast enhancement, high perfusion, unrestricted diffusion, and specific MRS metabolic patterns, to aid in their accurate diagnosis.
This mixed-methods study reveals that surrogate decision-makers report significantly lower confidence in acute scenarios compared to general ones, with self-efficacy emerging as the strongest predictor of confidence across both contexts, suggesting that targeted preparation to boost self-efficacy could improve decision-making readiness.
This Level I randomized controlled trial demonstrates that while both endoscopic and mini-open carpal tunnel release are equally safe and effective for long-term outcomes, the endoscopic approach offers superior early pain reduction and faster return to work without increasing complication risks.
This retrospective cohort study of 374 critically ill SFTS patients demonstrates that invasive arterial blood pressure monitoring not only provides more accurate hemodynamic assessment during hypotensive shock but also significantly reduces the incidence and severity of upper limb skin ecchymosis compared to non-invasive monitoring.