📄 Category

medicine

5681 papers

📄 medicine

Acute kidney injury risk with SGLT2 inhibitors versus sulfonylureas by baseline cardiorenal status in type 2 diabetes: A nationwide cohort study

In a large nationwide Korean cohort study, initiating SGLT2 inhibitors as second-line therapy for type 2 diabetes was associated with a significantly lower 180-day risk of acute kidney injury compared to sulfonylureas, a protective effect that persisted in patients with heart failure but was attenuated among those with pre-existing chronic kidney disease.

Eonji Na, Hyeri Yang, Bonggi Kim, Sungho Won2026-07-03
📄 medicine

Perioperative Hemodynamic Disturbance as a Mediator Between Preoperative Pulmonary Hypertension and Acute Kidney Injury After Cardiopulmonary Bypass-assisted Cardiac Surgery: A Retrospective Cohort Study

This retrospective cohort study of 2,242 cardiac surgery patients demonstrates that postoperative vasopressor-inotropic requirements and intraoperative hypotension serve as significant, partially modifiable mediators linking preoperative pulmonary hypertension to an increased risk of acute kidney injury.

Zhou Zhou, Jinyi Shi, Wanxia Li, Rui Ding, Xuanyu Luan, Xinlong Zhang, Yang Zhang, Jiaxin Ren, Shiting Chen, Jialin Yin (…)2026-07-03
📄 medicine

Serum Lipid Biomarkers and Their Associations with Age-Related Macular Degeneration: A Cross-Sectional Analysis from the Beichen Eye Study

This cross-sectional analysis of the Beichen Eye Study involving 4,748 participants aged over 50 found that a higher triglyceride-to-HDL cholesterol ratio and lower triglyceride levels were associated with a reduced prevalence of age-related macular degeneration, while HDL cholesterol alone showed no independent association.

Gang Zou, Fei Gao, Limin Zhang, Xiaorong Li2026-07-03
📄 medicine

Three-dimensional anatomical characterization of the first jejunal trunk and its relative venous contribution

This study utilizes 3D-CT to characterize the anatomical variations of the first jejunal trunk (FJT) relative to the superior mesenteric artery, revealing that the Ventral type exhibits more cranial venous confluence and a greater relative venous contribution than the Dorsal type, which has significant implications for preoperative planning in pancreaticoduodenectomy.

Ryo Ataka, Yusuke Nakayama, Kazuhiko Kitaguchi, Yoshinobu Ikeno, Eiji Toyoda, Tetsuro Hirose2026-07-03
📄 medicine

Deep Learning-Based Whole-Body Lesion Segmentation and Automated OMIS Computation on [68Ga]Ga-DOTA-TOC PET/CT: Technical Feasibility of a SwinUNETR Pipeline for Pre-PRRT Bone Marrow Involvement Scoring

This study demonstrates the technical feasibility of a SwinUNETR-based deep learning pipeline for automated whole-body lesion segmentation and Osteo-Medullary Invasion Score (OMIS) computation on [68Ga]Ga-DOTA-TOC PET/CT, achieving performance comparable to expert inter-observer agreement and offering a reproducible tool for pre-PRRT risk stratification in neuroendocrine tumor patients.

Romain Ferrara, Solène Malmon, Salim Kanoun, Joris Cocquebert, Thibaut Reichert, Adil Moussali, Nathalie Charrier, Sébas (…)2026-07-03
📄 medicine

Successful Reversal of Tachycardia Induced Cardiomyopathy After Flecainide Therapy in an Infant With Focal Atrial Tachycardia

This case report describes the successful reversal of tachycardia-induced cardiomyopathy in a 4.5-month-old infant with focal atrial tachycardia through the prompt initiation of flecainide therapy, which restored sinus rhythm and led to the complete recovery of ventricular function and clinical status after initial rate-control strategies failed.

Arife Sancaktar, Tuğba Burcu Öztürk Gömeç, İrem Ersayoğlu2026-07-03
📄 medicine

Development and Internal Validation of a Simple Four-Variable Model for Predicting High-Risk Varices in Patients with Virally Suppressed HBV-Related Cirrhosis

This study developed and internally validated a simple four-variable model incorporating albumin, alanine aminotransferase, prothrombin time activity, and splenomegaly that demonstrates superior predictive accuracy for high-risk varices in patients with virally suppressed HBV-related cirrhosis compared to established non-invasive scores.

Xu Huang, Shaofei Wu, Wenhua Liu, Hao Zhuo, Ziheng Zhang, Yong An, Liwei Guo2026-07-03
📄 medicine

Transpulmonary pressures to predict the percentage of alveolar collapse and overdistension in acute respiratory distress syndrome

This study demonstrates that end-expiratory and end-inspiratory transpulmonary pressures accurately predict critical thresholds of alveolar collapse and overdistension in ARDS patients, yet EIT-guided PEEP titration yields higher pressures and improved recruitment compared to esophageal pressure-guided strategies, albeit with a trade-off of increased non-dependent overdistension.

Clément Brault, Yoann Zerbib, Romain Vallee, Rosalie Schoux, Alexis Lambour, Benjamin Swinyard, Valentin Dambrine, Julie (…)2026-07-03
📄 medicine

Adonertinib (FHND9041) versus Afatinib as First-line Treatment for Advanced Non-small-cell Lung Cancer with EGFR Sensitive Mutation (FHND9041-Ⅲ-01): A Multi-centre, Open-label, Randomised Phase 3 Trial

In a multi-centre, open-label, randomised phase 3 trial, adonertinib demonstrated significantly superior progression-free survival and a more favorable safety profile compared to afatinib as a first-line treatment for patients with advanced EGFR-mutated non-small-cell lung cancer, particularly those with Ex19del mutations.

Yuankai Shi, Puyuan Xing, Guowu Wu, Hongbo Wu, Xuhong Mi, Renping Wan, Chao Zhang, Yan Wang, Runxiang Yang, Hui Zhao, Ch (…)2026-07-03
📄 medicine

The projected dementia burden attributable to periodontal disease in England: a modelling study

This modelling study projects that the anticipated growth in periodontal disease prevalence in England could result in over 24,000 additional dementia cases and £548 million in annual societal costs by 2040, highlighting it as a highly prevalent but weak modifiable risk factor where population-level interventions may yield significant benefits despite minimal individual risk.

Edward Coote, Nitesh Patel, Rajesh Vijayanarayanan2026-07-03