5681 papers
This retrospective study of 434 children admitted with severe malaria at a tertiary hospital in South-East Nigeria reveals a 12.2% mortality rate, identifying age under five, urban residence, delayed presentation, and severe clinical complications like shock and impaired consciousness as significant independent predictors of death.
This study demonstrates that in non-diabetic obese children, insulin resistance (measured by HOMA-IR) is independently associated with the severity of obstructive sleep apnea, suggesting it could serve as a useful adjunct marker for identifying high-risk patients.
This prospective cohort study reveals that obesity and fibromyalgia are independent predictors of a "difficult-to-manage" psoriatic arthritis phenotype, which is associated with higher functional impairment, serious adverse events, and hospitalizations compared to non-difficult-to-manage cases.
This paper reports a successful case of complete resolution of refractory trigeminal neuralgia in a patient with autosomal dominant osteopetrosis type 1, achieved through a pretemporal extradural transcavernous approach that decompressed the nerve by addressing bony entrapment caused by petrous bone osteosclerosis.
This internet-based comparative cross-sectional study of students in South-East Nigeria reveals that while university health services in both public and private institutions only partially meet student needs, private university students report higher dissatisfaction and face distinct demographic differences, highlighting an urgent need for policy-driven improvements in staffing, infrastructure, and accessibility across Sub-Saharan African higher education.
This mixed-methods cohort study in conflict-affected Myanmar demonstrates that a nurse-led, community-based immunisation programme successfully re-established access and achieved full immunisation in 50% of zero-dose children, highlighting the critical role of community engagement and sustained follow-up despite significant logistical and security challenges.
This study of Northern Chinese patients reveals that early-onset type 2 diabetes is characterized by a more aggressive metabolic profile and a disproportionately higher age-standardized burden of microvascular complications, particularly nephropathy and retinopathy, compared to late-onset disease, underscoring the need for earlier, comprehensive risk assessment that includes factors like serum uric acid.
This scoping review of 57 studies reveals that while DBT Skills Training groups are widely implemented in outpatient settings to treat borderline personality disorder, there is substantial heterogeneity in their delivery across various parameters, indicating flexible adaptability but leaving uncertainty regarding the most effective implementation approaches.
This qualitative study involving 11 healthcare professionals and a consumer representative found that a dynamic consent platform (CoGenT) could effectively address time barriers and enhance understanding in precision oncology by complementing, rather than replacing, face-to-face discussions, provided it is tailored to specialty-specific needs and prioritizes privacy and usability.
This study presents an oral nanotherapeutic platform based on phytocarbon dots derived from *Dianthus superbus* that alleviates hepatic fibrosis by acting as molecular glues to induce the ubiquitination and proteasomal degradation of the upregulated protein ENO1, thereby suppressing the PI3K/AKT-Smad3 pathway.