medicine papers | Gist.Science

Associations of nine C-reactive protein-triglyceride-glucose index- derived adiposity phenotypes with incident cardiovascular-liver- metabolic multimorbidity: a prospective cohort study

This prospective cohort study of 6,534 Chinese adults demonstrates that nine C-reactive protein-triglyceride-glucose index (CTI)-derived adiposity phenotypes are significantly associated with the risk of incident cardiovascular-liver-metabolic multimorbidity, with the CTI-BMI index showing the strongest and most robust predictive performance.

Jing Chen, Zhonghua Sun, Jiajun Qiu, Zhongqing Zhou, Kaiqi Ma, Yongxin Liang, Chunqun Li, Shicong Liang2026-07-03

📄 medicine

Understanding Primary Care Physicians’ Comprehension of Eye Care Notes to Improve Diabetes Care Coordination

A cross-sectional survey of 82 primary care providers and endocrinologists reveals significant gaps in their ability to accurately interpret key elements of ophthalmology notes for diabetic retinopathy, highlighting the need for standardized documentation to improve inter-specialty care coordination.

Lauren E. Wedekind, Fritz Gerald P. Kalaw, Helena Gali, Kristen Kulasa, Kendall Moore, Quinn Quackenbush, Sally L. Baxte (…)2026-07-03

📄 medicine

ProToxNet: Expression-Aware Proteome-Wide Binding for Tissue-Stratified Adverse Event Prediction

ProToxNet is a novel framework that integrates proteome-wide drug–protein binding predictions with tissue-specific gene expression to accurately predict tissue-stratified adverse events for both known and novel drugs, demonstrating strong generalization and clinical validity across multiple benchmarks.

Vaibhava Lakshmi Ravideshik2026-07-03

📄 medicine

Association of perioperative acetate-buffered balanced crystalloid solution with postoperative myocardial injury after hip replacement: A retrospective cohort study

This retrospective cohort study of 865 hip replacement patients found that perioperative administration of acetate-buffered balanced crystalloid solution (SPMCG) was significantly associated with a reduced risk of postoperative myocardial injury within 3 and 7 days compared to non-SPMCG use.

Nanbo Luo, Niannian Shuai, Yanling Zhang, Jianming Chen, Zhao Zhao, Xinping Yang, Xiaoyang Huang, Wei You, Qingsheng Xue (…)2026-07-03

📄 medicine

Spatial Distribution and Environmental-Climatic Determinants of Malaria Infection Among Children Under Five in Liberia

This study analyzes the 2022 Liberia Malaria Indicator Survey data to reveal significant spatial heterogeneity in under-five malaria prevalence, identifying southern and southeastern hotspots driven by rainfall, vegetation, and water proximity, thereby advocating for geographically differentiated control strategies.

Richard Sagacity Tugbeh, Veliah Geetha, Samadou Tchakondo, Komi Selassi Gayi, George B. Davis, Josiah Brown Wilson, Ayao (…)2026-07-03

📄 medicine

Rapid Kidney Function Decline and Incident Hip Fracture in Older Adults: Evidence from CHARLS and HRS Cohorts

This study analyzed data from the China Health and Retirement Longitudinal Study (CHARLS) and the US Health and Retirement Study (HRS) to find that while rapid kidney function decline showed a trend toward increased hip fracture risk in older adults, the association was not statistically significant in either cohort.

Fan Zhang, Jie Zhu, Yan Bai, Yifei Zhong2026-07-03

📄 medicine

Concordance of a ChatGPT-4o–based triage model with emergency physician categorization in the emergency department: a prospective observational comparison with emergency medical technicians

This prospective observational study found that a ChatGPT-4o-based triage model demonstrated significantly higher concordance with emergency physician categorization than emergency medical technicians when using identical structured clinical data, though this agreement reflects rater consistency rather than diagnostic validity and is accompanied by a tendency to over-triage high-acuity patients.

Zülküf Sergen Ünlü, Murat Seyit, İbrahim Türkçüer, Atakan Yılmaz, Mert Özen, Alten Oskay2026-07-03

📄 medicine

Blocking the NEDD4L-ACE2 Ubiquitination Binding Site Alleviates Hypoxia-Induced Pulmonary Arterial Hypertension: A Mechanistic Study

This study identifies a specific ubiquitination binding site between NEDD4L and ACE2 and demonstrates that blocking this interaction via point mutation alleviates hypoxia-induced pulmonary arterial hypertension, revealing a novel therapeutic target for the disease.

Rui Wang, Rui Wang, Tianya Liu, Qianmin Chen, Zhiping Wang2026-07-03

📄 medicine

C5aR1 signaling in sensory neuron-associated macrophages drives neuropathic pain

This study identifies that C5a/C5aR1 signaling specifically activates sensory neuron-associated macrophages in the dorsal root ganglia to drive neuropathic pain via IL-1β, while excluding the involvement of C5aR1 in spinal microglia, peripheral injury-site macrophages, or primary nociceptive neurons.

Andreza Quadros, Conceição Anibal-Silva, Gabriel V. Lucena-Silva, Arthur S. Prudente, Alexandre G. M. Maganin, Glauce R. (…)2026-07-03

📄 medicine

Phenylephrine versus Norepinephrine for Hemodynamic Support in Tachycardic Septic Shock: A Propensity-Weighted Retrospective Cohort Study

In a propensity-weighted retrospective cohort study of septic shock patients with tachycardia, phenylephrine failed to improve heart rate control compared to norepinephrine and was associated with increased risks of new renal replacement therapy and fewer ventilator-free days, arguing against its routine use even in this specific population.

Yosep Shin, George Michael, Zachary Harris, Jonathan Koff, Dominic Mancini, Bilori Bilori, Kathleen Chaisson, Youjin Lee2026-07-03

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