5683 papers
This study demonstrates that native Silymarin extract exhibits superior anticancer efficacy and selectivity against colon cancer cells compared to its nanomodified form by inhibiting MAPK proliferation pathways and activating P53-mediated apoptosis while sparing normal epithelial cells.
This study evaluated the reporting quality of 40 prosthodontics-related systematic reviews published in SCI-E journals between 2010 and 2019 using the PRISMA checklist, finding that while quality has significantly improved over time with publication year as the only significant predictor, important deficiencies in adherence to reporting standards remain.
This cross-sectional network analysis of 271 vocational undergraduate nursing interns reveals that work-related disappointment and professional happiness are central to compassion fatigue and professional identity respectively, while competence utilization serves as the critical bridge node linking these constructs through negative associations.
This paper reports two cases of fatal and non-fatal aconitine poisoning resulting from the ingestion of improperly processed Chinese herbal medicines, highlighting the severe cardiotoxic and neurotoxic risks associated with *Aconitum* species and emphasizing the urgent need for enhanced public awareness and rational clinical use to prevent future adverse events.
This case report describes a rare instance of placenta percreta in a healthy, primiparous woman without classic risk factors, emphasizing the critical importance of maintaining high clinical suspicion for early diagnosis and timely surgical intervention to ensure favorable maternal and fetal outcomes.
This study triangulates literature, expert, and older adult perspectives to demonstrate that inclusive design for digital health interventions targeting older adults must extend beyond usability and accessibility to encompass emotional, ethical, and systemic dimensions, with a strong consensus on the foundational importance of personalization and ongoing user support.
This study demonstrates that an AI-equipped digital stethoscope achieves higher sensitivity than blinded human reviewers in detecting audible heart murmurs in emergency department patients, although both methods struggle with inaudible structural heart disease.
This causal analysis of two intensive care databases reveals that deep sedation during the first 48 hours of mechanical ventilation is significantly associated with increased 28-day mortality in adult patients with sepsis compared to light sedation.
This case report highlights a 24-year-old man who sustained a high-voltage electrical injury to the left upper extremity, demonstrating that relatively localized external burns can mask profound internal muscle damage and severe rhabdomyolysis, thereby underscoring the critical need for serial laboratory monitoring and multidisciplinary management even when initial hemodynamic and renal parameters appear normal.
This hospital-based matched case-control study conducted in Central India identified low socioeconomic status, early reproductive milestones, high parity, poor genital hygiene, and tobacco chewing as significant predictors of cervical cancer, highlighting the need for targeted socioeconomic and health education interventions to reduce the disease burden.