📄 Category

medicine

5683 papers

📄 medicine

Illustrative Integration of Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) Data in Dose-Cohort Review for a Phase I Clinical Trial

This paper illustrates how integrating Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) with clinician-graded CTCAE data in a Phase I acute myeloid leukemia trial provides a more comprehensive assessment of patient symptom burden and tolerability to inform dose-escalation decisions.

Carolyn Mead-Harvey, Brie Noble, Claire Yee, Gina Mazza, Blake Langlais, Sheetal Patel, Peter Trask, Lauren Rogak, Ethan (…)2026-07-02
📄 medicine

Mismatch between Urban Eco-sanitation Improvement and Health Service Supply Capacity: Evidence from Chinese City Panel Data and Interpretable Machine Learning

Using panel data from Chinese cities and interpretable machine learning, this study reveals that while urban eco-sanitation conditions have improved, they do not automatically translate into enhanced health service supply capacity due to a mismatch in resource allocation and fiscal mechanisms, necessitating an integrated governance framework to bridge the gap.

Zhen Peng, Lin Wang2026-07-02
📄 medicine

Protease activity in plasma extracellular vesicles enables diffuse large B-cell lymphoma detection, relapse- and therapy monitoring

This study presents a sensitive, cost-effective liquid biopsy assay that measures protease activity in plasma extracellular vesicles to accurately detect diffuse large B-cell lymphoma, predict treatment response, and monitor disease relapse.

Andreas Baur, Xin Lai, Jan Van Deun, Rebecca Bauer, Jan-Ole Baur, Kristin Mentz, Fabian Müller, Andreas Gießl, Andreas M (…)2026-07-02
📄 medicine

European LeukemiaNet Clinical Signs and Symptoms as Prognostic Markers in Polycythemia Vera During Ruxolitinib

This study demonstrates that European LeukemiaNet-defined clinical signs and symptoms serve as superior prognostic markers for predicting thrombosis and disease progression in polycythemia vera patients treated with ruxolitinib, outperforming conventional risk stratification methods.

Filippo Branzanti, Francesca Palandri, Elena Rossi, Massimo Breccia, Elena Elli, Chiara Sartor, Alessandra Dedola, Aless (…)2026-07-02
📄 medicine

Characterization of acute dengue immune status and the role of serotypes in transmission dynamics in three regions of Burkina Faso: a hospital-based cross-sectional study

This hospital-based cross-sectional study in Burkina Faso characterizes acute dengue immune status and transmission dynamics, revealing a predominance of primary infections and DENV-1/3 circulation, validating a rapid diagnostic test for immune status differentiation, and suggesting the Qdenga vaccine as a relevant intervention option.

Louis Robert Wendyam Belem, Arsène Zongo, Raymond Karlhis Yao, Christelle Lankouandé, Armand Vital Wenceslas Taïta, Tarw (…)2026-07-02
📄 medicine

Early Regression of Hepatic Steatosis after Bariatric Surgery Assessed by Ultrasound Including Attenuation Imaging

This prospective study demonstrates that hepatic steatosis regresses significantly within the first three to six months following bariatric surgery, with quantitative Attenuation Imaging (ATI) proving more sensitive than standard B-mode ultrasound for detecting these early improvements and enabling precise longitudinal monitoring.

Tatjana Hoffmann, Daniel Wulff, Sabrina Groß, Bariya Bajwa, Gunnar Blumenstock, André Mihaljevic, Nisar Malek, Lisa Minn2026-07-02
📄 medicine

Risk of Desmoid Tumor Based on APC Pathogenic Variant Location and Surgical History in Familial Adenomatous Polyposis: A U.S. Community Cohort Study

In a large U.S. community-based cohort of patients with familial adenomatous polyposis, the study identifies that central *APC* variant location, family history, and prior colorectal surgery are significant independent risk factors for developing desmoid tumors, whereas non-colorectal surgery is not.

Prakash Thomas, Holly Carwana, Sheng-Fang Jiang, Janet Song, Dan Li2026-07-02
📄 medicine

A Practical Scoring System for Conversion Therapy Stratification in Intermediate-Stage Hepatocellular Carcinoma

This study presents and externally validates the CATCH score, a practical three-factor tool (incorporating albumin–bilirubin score, BMI, and des-γ-carboxyprothrombin) that effectively stratifies patients with intermediate-stage hepatocellular carcinoma to identify candidates most likely to achieve successful conversion therapy with atezolizumab plus bevacizumab.

Kenichi Taguchi, Yasuto Takeuchi, Masahiko Sue, Takuya Adachi, Hideki Onishi, Miwa Kawanaka, Akinobu Takagi, Kenji Kuwak (…)2026-07-02
📄 medicine

Proximity without sovereignty: community-led responses and the UNAIDS 30-80-60 targets in HIV governance in Kinshasa, DRC: a qualitative study

This qualitative study in Kinshasa reveals that despite the vital role of community actors in HIV service delivery, their influence remains limited to consultation rather than strategic decision-making—a condition termed "proximity without sovereignty"—which necessitates structural reforms like core funding and legal protections to achieve genuine community-led governance.

KANA LINGAMBU Olivier, Silvia ROSSI, MAINDO ALONGO Mike-Antoine, KAMBAMBA MANDEKI Dina, Philippe LUKANU2026-07-02
📄 medicine

Plasma proteomic profiling reveals distinct molecular signatures associated with coronary collateral circulation in patients with chronic total occlusion

This study utilizes plasma proteomic profiling to identify distinct molecular signatures and develop a high-accuracy machine learning model that effectively predicts coronary collateral circulation status and stratifies cardiovascular risk in patients with chronic total occlusion.

Yi-Ning yang, Jun-Yi Luo, Peng Ran, Fen Liu, Ya-Jing Qiu, Bin-Bin Fang, Yunzhi Wang, Sha Tian, Xiao-Mei Li, Chen Ding2026-07-02