📄 medicine

Physiological comparison of high-flow oxygen via endotracheal tube and T-piece strategies during spontaneous breathing trials: a randomized crossover study

This randomized crossover study demonstrates that high-flow oxygen delivered via an endotracheal tube, particularly with smaller expiratory ports and higher flow rates, generates beneficial pressure-dependent physiological effects—including improved lung volume, oxygenation, and reduced dynamic stress—while maintaining inspiratory effort comparable to post-extubation levels, positioning it as a promising alternative to T-piece strategies for spontaneous breathing trials.

Shan-Shan Xu, Rui-Zhi Zhang, Jun-Tong Liu, Lin Wang, Meng-Xue Hou, Xu An, Ming-Yue Miao, Hong-Liang Li, Yue-Fu Wang, Jia (…)2026-07-02
📄 medicine

Rapid evaluation of risk communication and population acceptance following detections of vaccine-derived poliovirus in wastewater, Germany, 2024–2025

Despite high overall vaccine acceptance in Germany following 2024–2025 wastewater poliovirus detections, limited risk communication achieved only moderate reach and failed to close vaccination gaps, particularly among parents with populist political orientations who exhibited lower trust and uptake.

Julia Neufeind, Cornelius Rau, Johannes Lemcke, Ole Wichmann, Nora Schmid-Küpke2026-07-02
📄 medicine

Outcomes of Laparoscopic Versus Open Excision of Choledochal Cyst in Preschool-Aged Children: Analysis From a Nationally Representative Database

This study utilizing a nationally representative database found that while laparoscopic and open excision of choledochal cysts in preschool-aged children yield similar short-term complication rates, the laparoscopic approach offers superior perioperative recovery, reduced resource utilization, and shorter hospital stays.

Maria Grazia Sacco Casamassima, Nadeen Alturki, Janelle R. Noel-MacDonnell, Tolulope A Oyetunji, Shawn D. St. Peter2026-07-02
📄 medicine

Clinicopathological factors associated with brain metastases development among breast cancer patients receiving neoadjuvant chemotherapy

This retrospective study of 586 breast cancer patients receiving neoadjuvant chemotherapy identifies residual nodal involvement, inflammatory breast cancer, and HER2-positive or triple-negative subtypes as independent predictors of earlier brain metastasis development, suggesting a need for further investigation into targeted screening for these high-risk groups.

Jie Wei Zhu, Italo Fernandes, Julia Lopes, Veronika Moravan, William Tran, Katarzyna Jerzak2026-07-02
📄 medicine

Molar Incisor Hypomineralization and Self-perception of Mother's Positive Oral Health - a Comparative Cross-sectional Study

This comparative cross-sectional study found that mothers of children with Molar Incisor Hypomineralization (MIH), particularly severe cases, reported a lower self-perception of positive oral health compared to mothers of children without MIH, while higher maternal education levels were associated with a more positive oral health self-perception.

Letícia Cristine-Silva, Saul Martins Paiva, Jéssica Madeira Bittencourt, Raquel Vieira Vieira-Andrade, Marco Aurelio Ben (…)2026-07-02
📄 medicine

Tetrastigma hemsleyanum protects against sepsis-induced intestinal injury by suppressing TLR4/NF-κB signaling and macrophage polarization

Tetrastigma hemsleyanum protects against sepsis-induced intestinal injury in rats by modulating the gut microbiota–macrophage–TLR4/NF-κB axis, which suppresses inflammation, promotes M2 macrophage polarization, and restores intestinal barrier integrity.

Lisha Pang, Muhua Dai, Wei Zhang, Jianbiao Meng, Chunlian Ji, Jiayan Li, Jiahua Chi, Mahong Hu, Zhipeng Xu2026-07-02
📄 medicine

Fluctuating Arousal Failure with Repeatedly Negative DWI Preceding Artery of Percheron Infarction: A Case Report and Focused Literature Review

This case report describes a 65-year-old man who experienced recurrent transient arousal failure and ocular motor signs with initially negative DWI scans, ultimately diagnosed as an Artery of Percheron infarction, highlighting the critical need to prioritize clinical localization and serial imaging over normal early MRI findings when suspecting posterior-circulation stroke.

Yuke Ma, Hao Li, Jia Fan2026-07-02