5683 papers
This multicenter Italian retrospective study demonstrates that IRRAflow®-based active cerebrospinal fluid exchange is a feasible and generally safe real-world intervention for managing difficult CSF in neurocritical care, showing significant clinical improvement despite higher adverse event rates in infectious compared to hemorrhagic cases.
The University of Central Florida's "Clinician Educator" model addresses primary care shortages and traditional clerkship limitations by restructuring outpatient training to prioritize student autonomy, standardized teaching, and skill development through a modified clinic workflow that balances educational goals with clinical productivity.
This systematic review and meta-analysis of 45 prospective studies involving over 48,000 adults found that while greater baseline flexibility is weakly associated with reduced risks of future pain, disability, and frailty, current evidence provides limited support for flexibility as an independent predictor of broader health outcomes due to methodological limitations and low certainty of evidence.
This systematic review and meta-analysis of 35 prospective cohort studies concludes that while general flexibility shows limited value as a prognostic marker for chronic conditions, specific joint range-of-motion assessments may offer clinical utility for certain diseases like osteoarthritis and ankylosing spondylitis, though high-quality longitudinal evidence remains scarce for most major chronic conditions.
This prospective study of 28 oral cavity cancer patients undergoing radiotherapy found that while mucositis is the most common complication, the development of oral adverse effects appears to be driven by multifactorial mechanisms rather than being solely dependent on radiation dose, volume, or tumor localization, underscoring the need for multidisciplinary oral management.
In a propensity score-matched analysis of T3N0M0 colon cancer patients, adjuvant chemotherapy did not improve overall survival for those with adverse histological features generally, but significantly benefited cancer-specific survival specifically in female patients aged 70 years or older.
This cross-sectional study of 300 patients with gynecologic malignancies reveals that higher AI literacy is significantly associated with reduced both subjective and objective healthcare-seeking delays, whereas higher AI trust is linked only to lower subjective delays.
This institutional mixed-methods study conducted in Bahir Dar, Ethiopia, reveals that postpartum depression literacy among antenatal care attendees is generally poor (24%) and is significantly associated with urban residence, moderate social support, and a history of postpartum depression, highlighting the urgent need for targeted educational interventions.
This paper presents a case series of two patients with chronic kidney disease who developed advanced chronic tophaceous gout characterized by rare axial and atypical joint involvement, highlighting the diagnostic challenges posed by such presentations that mimic other musculoskeletal disorders.
This study utilizes a comprehensive multi-method framework on NFHS-5 data to reveal that Minimum Dietary Diversity among Indian children remains critically low and spatially clustered with stunting, driven primarily by maternal education and wealth inequalities, while finding no statistically significant impact from the Aspirational Districts Programme.