5683 papers
This study developed and validated a high-performing XGBoost predictive model, utilizing five core clinical predictors identified via LASSO regression, to accurately assess the 6-month rebleeding risk in cirrhotic patients with esophagogastric variceal bleeding.
This target trial emulation using MIMIC-IV and eICU-CRD data reveals that initiating furosemide during active norepinephrine infusion is associated with a significant increase in proximal hemodynamic destabilization and acute kidney injury without a detectable short-term mortality benefit, suggesting a need for careful timing in vasopressor-dependent patients.
This retrospective study identifies and validates plasma BAK1 as a novel machine learning-derived biomarker that effectively predicts short-term treatment response and long-term survival outcomes in patients with locoregionally advanced nasopharyngeal carcinoma.
This study concludes that both arthroscopic intertubercular groove and suprapectoral tenodesis combined with rotator cuff repair effectively treat small supraspinatus tears with long head of biceps tendon lesions, though the choice between techniques should be guided by patient-specific demands given the early functional advantages of the intertubercular approach and the distinct pathological characteristics of the tendon zones.
This cross-sectional study of 88 patients with chronic respiratory diseases found that *Lophomonas blattarum* infection has a notable prevalence of 26.1%, is significantly associated with exposure to environmental vectors like cockroaches, and responds well to metronidazole therapy.
This randomized controlled trial demonstrates that a novel acupuncture point combination incorporating "Three Shen" head points is safe and more effective than standard peri-knee acupuncture alone in reducing pain and anxiety for knee osteoarthritis patients, potentially mediated by increased serum 5-hydroxytryptamine levels.
This study utilized an Experience-Based Co-Design (EBCD) process involving 103 diverse stakeholders in Sindh, Pakistan, to identify critical training gaps and operational barriers among frontline immunization workers, ultimately translating these insights into a blueprint for an AI-powered digital learning platform tailored to low-resource settings.
This convergent mixed-methods study of 391 Palestinian medical students reveals a high prevalence of psychological distress (66%) and identifies key independent predictors—including unhealthy diet, lack of moral support, low motivation, living alone, and political anxiety—highlighting the urgent need for context-sensitive, multi-level support systems to address the interplay of academic, lifestyle, and socio-political stressors.
This randomized controlled trial found that while a 3-month remote multidisciplinary intervention for patients with weight regain after sleeve gastrectomy did not result in significant weight loss compared to a single consultation, it successfully improved lower extremity strength, physical activity, and grazing behaviors.
This study demonstrates that the calcium-sensing receptor (CaSR) suppresses liver fibrosis by coupling with TRPV4 to mediate calcium influx, which triggers reactive oxygen species accumulation and promotes the apoptosis of activated hepatic stellate cells, suggesting that restoring calcium signaling could be a therapeutic strategy for limiting fibrotic progression.