5683 papers
A short, locally led, simulation-based curriculum delivered by in-country faculty in Ethiopia significantly improved laparoscopic knowledge and technical skills among surgeons and trainees, demonstrating that sustainable, locally owned training models can effectively expand minimally invasive surgery capacity in low-resource settings.
This study introduces an auditable, human-arbitrated dual-LLM workflow for methodological quality assessment in preclinical complex-intervention research, demonstrating that leveraging LLM disagreement as a signal for targeted human review effectively identifies systematic methodological weaknesses while ensuring transparency and accuracy.
This in vitro study demonstrates that zirconia-reinforced lithium disilicate exhibits superior translucency compared to super-high-translucent zirconia at both 0.9 mm and 1.3 mm thicknesses, despite both materials showing reduced translucency as thickness increases.
This retrospective study of 429 men with metastatic androgen pathway modulator-resistant prostate cancer treated with sipuleucel-T identifies *MYC* gain as the strongest independent genomic predictor of poor overall survival, alongside clinical factors such as extensive bone metastases, older age, and elevated alkaline phosphatase.
Novel poly-target 2,3-benzodiazepine derivatives, MPTD-01 and BS34-20, significantly improved neurological recovery and survival while attenuating reactive astrogliosis in a rat model of traumatic brain injury, supporting their potential as multi-target neuroprotective agents.
This study identifies sepsis and early fluid overload as independent risk factors for necrotizing enterocolitis in preterm infants and demonstrates that a predictive model combining these clinical factors with elevated serum spermine oxidase (SMOX) and acrolein (ACR) levels offers high accuracy for early NEC detection.
This paper outlines a multidisciplinary approach to skull base tumor management, emphasizing the importance of early diagnosis, osteocutaneous exposure techniques for en bloc resection, and the use of free tissue transfers for reconstruction, based on the authors' experience with 32 patients.
This prospective cohort study demonstrates that colonoscopy exhibits substantial concordance with histopathology and excellent accuracy for malignancy detection, while also validating the clinical utility of routine biopsy in macroscopically normal mucosa, which revealed significant inflammatory pathology in approximately one-fifth of cases.
This study demonstrates that a tertiary medical centre in the Middle East successfully maintained 67% of its baseline surgical activity during the 2026 regional conflict despite a 71% reduction in operating room capacity by implementing a structured 4S (Staff, Stuff, Space, and System) operational framework that balanced service continuity with mass casualty readiness and workforce well-being.
This cohort study identifies extensive talar bone marrow lesions, severe tibiotalar joint effusion, elevated anxiety and depression levels, and impaired walking function as independent predictors of conservative treatment failure requiring surgical intervention in young and middle-aged male patients with first-time acute lateral ankle sprains.