5683 papers
This multinational study validates the 24-item Pharmacology Concept Inventory (PCI) as a reliable, unidimensional, and diagnostically informative tool for assessing conceptual understanding and identifying specific misconceptions across diverse international student cohorts.
In a cross-sectional study of 1,840 routine health examination participants, higher levels of systemic inflammatory biomarkers—specifically the neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI)—were found to be independently and positively associated with elevated intraocular pressure, suggesting a link between systemic inflammation and IOP regulation.
This study demonstrates that having patients perform their own neck encirclement significantly improves the availability of neck circumference data for the NoSAS OSA screening tool in routine practice without compromising diagnostic accuracy.
This paper introduces "Paralogue Annotation," a high-precision computational framework that leverages known pathogenic variants in homologous proteins to accurately predict disease-causing missense variants, offering a complementary and scalable approach for clinical genetic interpretation.
This cross-sectional study of 1,872 Chinese older adults reveals that higher physical exercise frequency significantly enhances subjective well-being, a relationship that is partially mediated by improved self-rated health and reduced depressive symptoms, with stronger effects observed among men, those aged 70 or older, and individuals with better socioeconomic status or spousal co-residence.
This paper outlines the design and rationale of a pilot randomized study evaluating the feasibility, acceptability, and implementation of a digital health intervention for lifestyle management in adults with metabolic syndrome to inform future definitive trials.
This systematic review and meta-analysis of 381 patients indicates that while biopsy-free radical prostatectomy for suspected clinically significant prostate cancer results in a high proportion of confirmed significant disease on final pathology, the approach is supported only by very low-certainty evidence due to high bias and heterogeneity, warranting its restriction to prospective studies rather than standard clinical practice.
This qualitative study of Muslims in London reveals that discrimination, Islamophobia, and stigma—both experienced and anticipated within and beyond healthcare settings—act as significant structural barriers to diabetic retinopathy screening attendance, necessitating culturally safe care and anti-racist training to improve equitable access.
This one-stage individual participant data meta-analysis of 11 studies identifies the optimal daily compositions of sleep, sedentary behavior, light physical activity, and moderate-to-vigorous physical activity associated with a healthy weight for children, adolescents, adults, and older adults, providing evidence to inform lifespan movement behavior guidelines.
This randomized crossover trial demonstrates that combining transcranial alternating current stimulation (tACS) with neuromuscular electrical stimulation (NMES) is safe and feasible for chronic stroke hand rehabilitation, showing promising but non-significant exploratory functional improvements and reduced sleepiness in a small cohort.