6109 papers
This cross-sectional analysis of the Beichen Eye Study involving 4,748 participants aged over 50 found that a higher triglyceride-to-HDL cholesterol ratio and lower triglyceride levels were associated with a reduced prevalence of age-related macular degeneration, while HDL cholesterol alone showed no independent association.
This study utilizes 3D-CT to characterize the anatomical variations of the first jejunal trunk (FJT) relative to the superior mesenteric artery, revealing that the Ventral type exhibits more cranial venous confluence and a greater relative venous contribution than the Dorsal type, which has significant implications for preoperative planning in pancreaticoduodenectomy.
This study demonstrates the technical feasibility of a SwinUNETR-based deep learning pipeline for automated whole-body lesion segmentation and Osteo-Medullary Invasion Score (OMIS) computation on [68Ga]Ga-DOTA-TOC PET/CT, achieving performance comparable to expert inter-observer agreement and offering a reproducible tool for pre-PRRT risk stratification in neuroendocrine tumor patients.
This case report describes the successful reversal of tachycardia-induced cardiomyopathy in a 4.5-month-old infant with focal atrial tachycardia through the prompt initiation of flecainide therapy, which restored sinus rhythm and led to the complete recovery of ventricular function and clinical status after initial rate-control strategies failed.
This study developed and internally validated a simple four-variable model incorporating albumin, alanine aminotransferase, prothrombin time activity, and splenomegaly that demonstrates superior predictive accuracy for high-risk varices in patients with virally suppressed HBV-related cirrhosis compared to established non-invasive scores.
This study demonstrates that end-expiratory and end-inspiratory transpulmonary pressures accurately predict critical thresholds of alveolar collapse and overdistension in ARDS patients, yet EIT-guided PEEP titration yields higher pressures and improved recruitment compared to esophageal pressure-guided strategies, albeit with a trade-off of increased non-dependent overdistension.
In a multi-centre, open-label, randomised phase 3 trial, adonertinib demonstrated significantly superior progression-free survival and a more favorable safety profile compared to afatinib as a first-line treatment for patients with advanced EGFR-mutated non-small-cell lung cancer, particularly those with Ex19del mutations.
This modelling study projects that the anticipated growth in periodontal disease prevalence in England could result in over 24,000 additional dementia cases and £548 million in annual societal costs by 2040, highlighting it as a highly prevalent but weak modifiable risk factor where population-level interventions may yield significant benefits despite minimal individual risk.
This retrospective study of 434 children admitted with severe malaria at a tertiary hospital in South-East Nigeria reveals a 12.2% mortality rate, identifying age under five, urban residence, delayed presentation, and severe clinical complications like shock and impaired consciousness as significant independent predictors of death.
This study demonstrates that in non-diabetic obese children, insulin resistance (measured by HOMA-IR) is independently associated with the severity of obstructive sleep apnea, suggesting it could serve as a useful adjunct marker for identifying high-risk patients.