6238 papers
This study demonstrates that while host adaptive immunity limits sustained optogenetic expression in skeletal muscle for treating obstructive sleep apnea, a combination of rapamycin and cyclosporin effectively mitigates this immune response to preserve durable transgene expression and functional muscle activation.
This retrospective cohort study demonstrates that the intelligent pneumoperitoneum system (Zhonghe Third-Generation) significantly improves hemodynamic stability, reduces vasopressor requirements, and shortens operative time in robotic pheochromocytoma resection compared to conventional methods.
This study presents a stimulus-responsive MnO2-based nanoswitch that utilizes intraplaque H2O2 to simultaneously generate oxygen, reprogram pro-inflammatory macrophages, and activate photodynamic therapy, thereby effectively treating hypoxic atherosclerotic plaques while minimizing off-target toxicity.
This study utilizes high-plex proteomic profiling of circulating extracellular vesicles from NSCLC patients to identify a six-protein signature that predicts immune checkpoint inhibitor resistance and reveals distinct immune evasion mechanisms associated with poor treatment outcomes.
This bibliometric analysis of 5,463 publications from 2010 to 2026 maps the global Benign Prostatic Hyperplasia research landscape, revealing China's dominance in output, the United States' leadership in collaboration, and a significant paradigm shift from traditional surgical interventions toward inflammation-driven mechanisms and minimally invasive therapies.
The paper introduces CEMR-ECG, a traceable decision-layer framework that integrates rhythm, morphology, and prototype evidence with backbone classifiers to significantly improve macro-averaged F1 scores and address class imbalance in AAMI-style ECG heartbeat classification across multiple datasets.
This 2024 cross-sectional study of 243 emergency department nurses in Ardabil, Iran, reveals that lateral violence is highly prevalent and significantly correlated with specific personality traits, particularly noting that higher neuroticism and lower extraversion are associated with increased exposure to and underreporting of workplace aggression.
In a large retrospective study of over 7,600 patients within an integrated health system, weekend admission for upper gastrointestinal bleeding was not associated with increased in-hospital mortality or other adverse outcomes, suggesting that standardized 24/7 care pathways effectively eliminate the "weekend effect" in this condition.
This study demonstrates that while Retatrutide treatment in streptozotocin-induced diabetic rats significantly attenuates HIF-1α upregulation and shows a non-significant trend toward reducing renal inflammation and histopathological injury, it does not yet confer overt structural renoprotection, suggesting that longer durations or chronic disease models are needed to confirm its therapeutic potential.
This cross-sectional study of 6,096 participants in Sierra Leone reveals that while misconceptions about mpox (such as viewing it as a divine curse or government propaganda) significantly undermine prevention and control practices, stigma does not independently affect these behaviors, highlighting the need for targeted risk communication to address false beliefs.