6238 papers
This study integrates multi-cohort transcriptomic meta-analysis and molecular docking to identify DRD2 and SLC18A3 as core hub genes for a novel Parkinson's disease diagnostic model and proposes donepezil and bromocriptine as potential therapeutic ligands targeting pyroptosis and neuroinflammation pathways.
This study establishes that trauma accounts for over 20% of emergency department visits at Oshakati Intermediate Hospital in Namibia, disproportionately affecting young unemployed males, with alcohol consumption identified as a critical modifiable risk factor driving violence and accidents, thereby highlighting the urgent need for strengthened trauma care systems and targeted prevention strategies.
This prospective observational study demonstrates that the hybrid convergent procedure for atrial fibrillation offers a favorable perioperative profile with low major complication rates and short ICU stays, despite common early postoperative pericarditis and arrhythmias, while achieving meaningful long-term rhythm control in the majority of patients.
A 2020 cross-sectional study at a Namibian referral hospital reveals that over half of healthcare workers experienced sharps injuries, with doctors reporting higher injury frequencies and lower safety compliance compared to nurses, highlighting the urgent need for targeted institutional interventions and improved workplace safety systems beyond mere awareness.
A 2020 cross-sectional study at Intermediate Hospital Oshakati in Namibia reveals that healthcare workers, particularly doctors, exhibit significant knowledge gaps and suboptimal attitudes regarding medical sharps handling and injury reporting, highlighting an urgent need for targeted educational interventions and improved post-exposure protocols.
This mini literature review synthesizes evidence from 2020 to 2025 demonstrating that active smoking, second-hand smoke exposure, and electronic cigarette use all significantly contribute to respiratory morbidity through overlapping inflammatory and oxidative stress mechanisms, underscoring the urgent need for comprehensive tobacco control and regulation of emerging nicotine delivery systems.
This MRI study demonstrates that the anterior-to-psoas corridor for oblique lumbar interbody fusion narrows progressively from L1 to L5 and is modestly widened by right-lateral positioning, indicating that preoperative imaging in the surgical position is essential to determine safe cage dimensions and the potential need for psoas retraction.
This paper proposes and evaluates a conceptual MEMS-enabled framework that utilizes a subset of EEG-derived features from a large dataset to develop the Smart MEMS Sedation Monitoring and Risk Index (SMORI), a unified metric for real-time anesthesia monitoring and overdose risk assessment.
This review explores the applications of artificial intelligence in optimizing analgesic drug therapy and pain management, highlighting its potential to improve patient outcomes, predict treatment responses, and reduce costs while addressing the extensive use of analgesics in hospital settings.
This updated systematic review and meta-analysis of 12 studies involving over 20,000 patients suggests that IVUS-guided PCI for unprotected left main coronary artery disease is associated with significantly lower rates of all-cause mortality, cardiac mortality, myocardial infarction, and target vessel revascularization compared to angiography-guided PCI, although these benefits were primarily driven by observational data while randomized controlled trials showed neutral results.