6238 papers
This study demonstrates that inhibiting EphB4 in breast cancer promotes immunogenic cell death and alters glucose metabolism via the Src/STAT3/MYC pathway, thereby transforming the tumor microenvironment from "cold" to "hot" and enhancing the efficacy of immunotherapy.
This study elucidates the mechanism by which *Angelicae Pubescentis Radix* (Duhuo) treats rheumatoid arthritis by integrating network pharmacology and experimental validation to demonstrate that its active constituents suppress synovial fibroblast proliferation and induce apoptosis through the inhibition of the PIK3CA/JAK2/PIK3CG signaling pathway.
This qualitative study involving 30 healthcare providers in the Yogyakarta region identifies substantial barriers within Indonesia's referral system for critically ill children, highlighting the urgent need to improve communication, human resources, and organizational services across pre-referral and referral facilities.
This community-based cross-sectional study of 100 vitiligo patients in Raichur, India, reveals that the condition imposes a severe psychosocial and economic burden, significantly impairing quality of life and daily functioning, thereby highlighting the urgent need for integrated community-level care involving dermatology, psychology, and pharmacy.
This study evaluates the feasibility of creating case-specific 3D-printed bone simulants from CT scans for ballistic testing, finding that while PLA and PA6-CF materials failed to replicate biological fracture and penetration characteristics, thermoplastic polyurethane (TPU) prototypes showed the most promising results.
This community-based study in Ibadan, Nigeria, reveals that maternal cervical cancer preventive practices for adolescent daughters are primarily driven by awareness and knowledge rather than risk perception, highlighting the critical need to strengthen health literacy to improve HPV vaccination uptake.
In a study of 940 adults at high risk of HIV in rural southwestern Uganda, 18.3% reported illicit non-injecting drug use, with significantly higher odds observed among sex workers, those with older sexual partners, individuals engaging with long-distance truck drivers or miners, and those having condomless sex with partners of unknown HIV status, highlighting the need for integrated substance abuse and HIV prevention strategies.
This cross-sectional study conducted at Bafoussam Regional Hospital in Cameroon found that 12.41% of people living with HIV on antiretroviral therapy had reduced glomerular filtration rate, a condition significantly associated with male gender, viral coinfections (HBV and HCV), comorbidities (diabetes and hypertension), advanced WHO disease stage, and the use of Tenofovir-based regimens.
This six-month prospective pilot study found that transitioning from daytime to night-time hemodialysis significantly improved dialysis adequacy and reduced severe pain and skin problems, although overall quality of life, sleep parameters, and biochemical markers remained unchanged.
This study demonstrates that argon inhalation attenuates liver and intestinal injury in neonatal mice with experimental sepsis by modulating the Toll-like receptor 4 signaling pathway and preserving intestinal barrier integrity, without causing adverse side effects.