6238 papers
This first-in-human study demonstrates that HIV-specific, HIV-resistant CAR T cells can effectively control viral rebound and promote sustained virologic remission in people with HIV, highlighting their potential as a key component of HIV cure strategies.
In a multicenter Korean cohort of heavily pretreated relapsed/refractory diffuse large B-cell lymphoma patients, glofitamab monotherapy demonstrated meaningful efficacy and a manageable safety profile, particularly for those with a longer treatment-free interval, while identifying rapid disease progression as a predictor of limited benefit.
This multicenter study demonstrates that in children undergoing MRI, autonomic regulation (measured by heart rate variability) influences diagnostic confidence and repeat-scan risk through a pathway mediated by psychological distress and behavioral dysregulation, with preparation interventions significantly improving these outcomes.
Through a realist evaluation of a prosthetic and orthotic care initiative in post-conflict Sierra Leone, this study develops the ROOTS framework, which establishes that sustainable outcomes depend on a specific, non-shortcuttable sequence of foundational local capacity conditions—infrastructure, supply chain reliability, workforce development, and technical quality assurance—rather than prioritizing patient volume alone.
This study developed and validated a machine learning-based penalized nomogram using 14 routine preoperative and intraoperative variables to accurately predict postoperative nausea and vomiting in patients undergoing thoracoscopic lung surgery, offering a practical tool for individualized risk stratification and prophylactic decision-making.
A cross-sectional study of 355 certified silicosis patients in Balesar Block, Rajasthan, reveals that 80.6% suffer from chronic respiratory disease symptoms, with continuous 8-hour daily work shifts and residing 6–10 km from quarries identified as the strongest independent predictors, underscoring the urgent need for stricter exposure limits and dust suppression measures.
A population-based survey in Jhargram, West Bengal, reveals that while cataract surgical coverage for blindness is high among tribal populations, significant gaps in effective coverage persist due to suboptimal surgical outcomes, gender disparities, and barriers such as lack of perceived need and fear of surgery.
This case report demonstrates that a structured 12-week physical therapy intervention delivered during hemodialysis sessions significantly improved functional strength, balance, and mobility in a young Ethiopian woman with end-stage renal disease, highlighting the potential of rehabilitation as an essential adjunctive care in low-resource settings.
A 2023 evaluation of the Pacific Public Health Surveillance Network (PPHSN) involving 149 respondents found that the network effectively strengthens regional surveillance and response through its six service arms, particularly as a communication platform and early warning system, while highlighting critical challenges in workforce retention, data reporting, and sustainable funding.
This paper proposes a transparent, multidimensional framework that identifies oncology early adopters under sparse real-world evidence by synthesizing clinical influence, patient opportunity, and therapeutic familiarity into a Euclidean readiness score, thereby enabling auditable prioritization for clinical education and evidence translation without relying on traditional labeled training data.