6238 papers
This study analyzes the 2022 Liberia Malaria Indicator Survey data to reveal significant spatial heterogeneity in under-five malaria prevalence, identifying southern and southeastern hotspots driven by rainfall, vegetation, and water proximity, thereby advocating for geographically differentiated control strategies.
This study analyzed data from the China Health and Retirement Longitudinal Study (CHARLS) and the US Health and Retirement Study (HRS) to find that while rapid kidney function decline showed a trend toward increased hip fracture risk in older adults, the association was not statistically significant in either cohort.
This prospective observational study found that a ChatGPT-4o-based triage model demonstrated significantly higher concordance with emergency physician categorization than emergency medical technicians when using identical structured clinical data, though this agreement reflects rater consistency rather than diagnostic validity and is accompanied by a tendency to over-triage high-acuity patients.
This study identifies a specific ubiquitination binding site between NEDD4L and ACE2 and demonstrates that blocking this interaction via point mutation alleviates hypoxia-induced pulmonary arterial hypertension, revealing a novel therapeutic target for the disease.
This study identifies that C5a/C5aR1 signaling specifically activates sensory neuron-associated macrophages in the dorsal root ganglia to drive neuropathic pain via IL-1β, while excluding the involvement of C5aR1 in spinal microglia, peripheral injury-site macrophages, or primary nociceptive neurons.
In a propensity-weighted retrospective cohort study of septic shock patients with tachycardia, phenylephrine failed to improve heart rate control compared to norepinephrine and was associated with increased risks of new renal replacement therapy and fewer ventilator-free days, arguing against its routine use even in this specific population.
This study elucidates that hemodynamic disruption in nephrotic syndrome triggers glomerular barrier injury via endothelial glycocalyx degradation, a mechanism validated through integrated in vivo and organ-on-a-chip models and shown to be effectively mitigated by sulodexide therapy.
This study demonstrates that a KMS-SECI-based educational module combined with video-assisted learning and husband support significantly improves knowledge, self-efficacy, and the rate of early breastfeeding initiation within one hour among primigravida mothers compared to conventional care.
This paper presents a complex postpartum trauma case to illustrate the diagnostic challenges of intraoperative pulmonary embolism under general anesthesia and proposes a structured, physiology-driven framework for clinical escalation that prioritizes objective deterioration over isolated risk factors or ambiguous markers.
This case report describes a woman with severe, cyclical recurrent mouth ulcers linked to hormonal fluctuations, which were successfully diagnosed as progesterone-induced and treated with Dexamethasone and Tamoxifen after extensive inconclusive testing.